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- Title
DRENAŻ ZEWNĘTRZNY TORBIELI RZEKOMEJ TRZUSTKI -- POWIKŁANIA STOSOWANIA L-ASPARAGINAZY U DZIECI Z CHOROBĄ NOWOTWOROWĄ.
- Authors
Piotrowska, Anna; Iwaszkiewicz, Krystyna; Sopyło, Barbara; Arłukiewicz-Piwowar, Małgorzata; Gadomski, Andrzej; Brzewski, Michał; Kamiński, Andrzej
- Abstract
L-asparaginase is used in the treatment of acute lymphoblastic leucemia (ALL) in children. Pancreatitis as a complication of this drug is treatment in 2-16% of patients. Progression of pancreatitis leads to pseudocysts formation in some case. Surgical treatment of pancreatic pseudocysts includes internal or external, either classical or laparo/endoscopic drainage. We present 2 pediatric patients (aged 5 and 7 years), who developed pancreatic pseudocyts. Typical clinical symptoms (abdominal pain, vomits, fever and abdominal mass) and biochemical manifestations (elevated serum and urine amylase levels) of pancreatitis were present. Ultrasound and CT scans showed pseudocysts of 3 cm and 12 cm in diameter, respectively. 4 weeks of intensive medical treatment management of pancreatitis was ineffective. Surgical external drainage of the psuedocysts was performed in consideration of patients poor condition. The drainage tubes were removed after 6 and 8 weeks, respectively. Repeated ultrasounds and CT showed involution of pseudocysts with no recurrence. Amylase serum and urine levels normalized. After 12 months and 36 months postoperatively children are healthy without dietary restrictions.
- Subjects
LEUKEMIA in children; ASPARAGINASE; PANCREATITIS; DISEASE complications; AMYLASES; SYMPTOMS; LEUKEMIA treatment; THERAPEUTICS
- Publication
Przeglad Pediatryczny, 2007, Vol 37, Issue 1, p148
- ISSN
0137-723X
- Publication type
Article