We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Post-infarct remodelling: contribution of wound healing and inflammation.
- Authors
Stefan Frantz; Johann Bauersachs; Georg Ertl
- Abstract
In human and experimental myocardial infarction (MI), cessation of blood supply leads to rapid necrosis of cardiac myocytes in the ischaemic heart. Immediately after injury, various intra- and intercellular pathways contribute to healing the myocardial wound in order to achieve tissue integrity and function. MI and the consequent loss of myocardium are the major aetiology for heart failure. Despite aggressive primary therapy, prognosis remains poor in patients with large infarction and severe left ventricular dysfunction. Thus, it would be highly desirable to improve healing of the cardiac wound to maintain structure and function of the heart. Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation.
- Subjects
VENTRICULAR remodeling; WOUND healing; INFLAMMATION; HEART necrosis; ISCHEMIA; HEART disease etiology; HEART cells
- Publication
Cardiovascular Research, 2009, Vol 81, Issue 3, p474
- ISSN
0008-6363
- Publication type
Article