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- Title
Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells.
- Authors
Han, Zhiyi; Miwa, Yoshikazu; Obikane, Hiyo; Mitsumata, Masako; Takahashi-Yanaga, Fumi; Morimoto, Sachio; Sasaguri, Toshiyuki
- Abstract
Aims: We investigated the mechanisms of shear stress (SS)-induced activation of cytochrome P450 (CYP) 1A1 and cell cycle arrest with regard to the role of the aryl hydrocarbon receptor (AhR), since AhR mediates the expression of CYP1A1 induced by polycyclic aromatic hydrocarbons (PAHs) and is thought to be involved in the regulation of cell growth and differentiation.
- Subjects
ARYLATION; CYTOCHROME P-450; CELL cycle; HYDROCARBONS; GROWTH factors
- Publication
Cardiovascular Research, 2008, Vol 77, Issue 4, p809
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvm095