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- Title
[<sup>18</sup>F]Nifene test-retest reproducibility in first-in-human imaging of α4β2* nicotinic acetylcholine receptors.
- Authors
Lao, Patrick J.; Betthauser, Tobey J.; Tudorascu, Dana L.; Barnhart, Todd E.; Hillmer, Ansel T.; Stone, Charles K.; Mukherjee, Jogeshwar; Christian, Bradley T.
- Abstract
The aim of this study was to examine the suitability of [18 F]nifene, a novel α4β2* nicotinic acetylcholine receptor (nAChR) radiotracer, for in vivo brain imaging in a first-in-human study. Methods: Eight healthy subjects (4 M,4 F;21-69,44 ± 21 yrs) underwent a [18F]nifene positron emission tomography scan (200 ± 3.7 MBq), and seven underwent a second scan within 58 ± 31 days. Regional estimates of DVR were measured using the multilinear reference tissue model (MRTM2) with the corpus callosum as reference region. DVR reproducibility was evaluated with test-retest variability (TRV) and intraclass correlation coefficient (ICC). Results: The DVR ranged from 1.3 to 2.5 across brain regions with a TRV of 0-7%, and did not demonstrate a systematic difference between test and retest. The ICCs ranged from 0.2 to 0.9. DVR estimates were stable after 40 min. Conclusion: The binding profile and tracer kinetics of [18F]nifene make it a promising α4β2* nAChR radiotracer for scientific research in humans, with reliable DVR test-retest reproducibility.
- Publication
Synapse, 2017, Vol 71, Issue 8, pn/a
- ISSN
0887-4476
- Publication type
Article
- DOI
10.1002/syn.21981