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- Title
Synthesis and Antibacterial and Antifungal Studies of Novel Nitrogen Containing Heterocycles from 5-Ethylpyridin-2-ethanol.
- Authors
PATEL, N. B.; PATEL, H. R.
- Abstract
A novel series of chalcones, pyrimidines and imidazolinone is described; chalcones (4a-o) were prepared from the ead molecule 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde. Pyrimidine (5a-o) derivatives were prepared from the reaction of chalcones and guanidine nitrate in alkali media. Imidazolinones (6a-o) were synthesized from reaction of pyrimidine and oxazolone derivatives (prepared by Erlenmeyer azlactone synthesis). The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, ¹H and 13C NMR spectral data. All the products were screened against different strains of bacteria and fungi. Most of these compounds showed better inhibitory activity in comparison to the standard drugs.
- Subjects
ANTIBACTERIAL agents; ANTIFUNGAL agents; ORGANIC synthesis; NITROGEN; ETHANOL; CHEMICAL structure; CLINICAL drug trials; NUCLEAR magnetic resonance spectroscopy; THERAPEUTICS
- Publication
Indian Journal of Pharmaceutical Sciences, 2010, Vol 72, Issue 5, p613
- ISSN
0250-474X
- Publication type
Article
- DOI
10.4103/0250-474X.78531