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- Title
Langerhans Cells Are Not Required for Efficient Skin Graft Rejection.
- Authors
Obhrai, Jagdeep S.; Oberbarnscheidt, Martin; Zhang, Na; Mueller, Daniel L.; Shlomchik, Warren D.; Lakkis, Fadi G.; Shlomchik, Mark J.; Kaplan, Daniel H.
- Abstract
The mechanism of skin allograft rejection has been thought to require presentation of graft antigen by resident epidermal Langerhans cells (LCs). We have previously engineered mice that have a selective and constitutive absence of epidermal LCs. By using donor skin from these LC-deficient mice, we show that LCs are not required for rejection of major (FVB → B6) or minor (H-Y, male → female on B6 background) antigen-mismatched skin grafts. On the FVB background, where H-Y mismatched grafts are normally maintained indefinitely, grafts lacking LCs are efficiently rejected. Thus, LCs in the donor graft are required for long-term skin engraftment, which supports a regulatory role for LCs in skin graft acceptance.JID JOURNAL CLUB ARTICLE: For questions, answers, and open discussion about this article please go to http://network.nature.com/group/jidclubJournal of Investigative Dermatology (2008) 128, 1950–1955; doi:10.1038/jid.2008.52; published online 13 March 2008
- Subjects
LANGERHANS cells; SKIN grafting; HOMOGRAFTS; TRANSPLANTATION of organs, tissues, etc.; SKIN diseases; IMMUNOHISTOCHEMISTRY; IMMUNE recognition
- Publication
Journal of Investigative Dermatology, 2008, Vol 128, Issue 8, p1950
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2008.52