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- Title
The protective role of IL-13 in Experimental Autoimmune Myocarditis.
- Authors
Cihakova, Daniela; Barin, Jobert G.; Afanasyeva, Marina; Kimura, Miho; Fairweather, DeLisa; Berg, Michael; Talor, Monica V.; Baldeviano, G. Christian; Frisancho, Sylvia; Gabrielson, Kathleen; Bedja, Djahida; McKenzie, Andrew N. J.; Rose, Noel R.
- Abstract
IL-13 knockout (KO) BALB/c mice developed severe myosin-induced experimental autoimmune myocarditis (EAM) and coxsackievirus B3 -- induced myocarditis with impaired cardiac function in some of the IL-13 KO mice. Total CD45+ leukocyte, B cell and macrophage were increased in the hearts of IL-13 KO mice. Spleen T cells from IL-13 KO mice were highly activated and had increased proliferation in vitro to myosin. Hearts of IL-13 KO mice had increased levels of the pro, inflammatory and profibrotic cytokines 1L-1b, IL-18, IFN-g, TGF-a, IL-4 and histamine. Severe EAM in IL-13 KO was not due to increased IL-4, as myocarditis was mild in IL-4 KO mice. CD4+CD25+Foxp3+ regulatory T cell numbers were not altered in the heart, but decreased in the spleen of IL-13 KO mice. Thus, IL-13 protects against severe myocarditis in BALB/c mice by inhibiting macrophage, T cells and B cell/antibody-mediated damage to the heart.
- Subjects
LABORATORY mice; MYOCARDITIS; COXSACKIEVIRUSES; LEUCOCYTES; B cells; MACROPHAGES
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA128
- ISSN
0892-6638
- Publication type
Article