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- Title
Three discipline collaborative radiation therapy (3DCRT) special debate: The single most important factor in determining the future of SBRT is immune response.
- Authors
Grassberger, Clemens; Huber, Kathryn; Jacob, Naduparambil K.; Green, Michael D.; Mahler, Peter; Prisciandaro, Joann; Dominello, Michael; Joiner, Michael C.; Burmeister, Jay
- Abstract
He studies the effects of radiation in combination with targeted therapies, and how radiotherapy can be used to delay resistance development or modulate the patient's immune response. SBRT has already been shown to spare the circulating lymphocytes compared to conventional fractionation in patients.[18] Especially in the context of combining radiation with immunotherapeutic approaches, radiation-induced depletion of lymphocytes can dampen synergistic effects,[19] and it has been shown that the predictive value of lymphocyte counts also holds for metastatic patients on treatment with checkpoint inhibitors receiving RT.[20] SBRT evolved from the success of brain stereotactic radiosurgery (SRS), a treatment technique that stereotactically delivers high doses of radiation to precisely defined cranial lesions.[29] The extension of stereotactic treatments extracranially required tools to ensure patients were appropriately immobilized, the target position was verified directly or through the use of surrogates (e.g., fiducial markers, neighboring anatomy), and target motion was minimized, as well as a delivery system that was capable of precisely delivering radiation to the intended target.
- Subjects
RADIOTHERAPY; FLUORODEOXYGLUCOSE F18; IMMUNE response; LYMPHOCYTE count; IMAGE-guided radiation therapy; MEDICAL specialties &; specialists; NON-small-cell lung carcinoma
- Publication
Journal of Applied Clinical Medical Physics, 2019, Vol 20, Issue 10, p6
- ISSN
1526-9914
- Publication type
Article
- DOI
10.1002/acm2.12728