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- Title
Spontaneous regression of brain arteriovenous malformations.
- Authors
Buis, Dennis R.; van den Berg, René; Lycklama, Geert; van der Worp, H. Bart; Dirven, Clemens M. F.; Vandertop, W. Peter
- Abstract
Objective and importance Complete spontaneous obliteration of a brain arteriovenous malformation (AVM) is a rare event, with 67 angiographically proven cases in the world literature.We present a new case and a systematic literature review to de- termine possible mechanisms underlying this unusual phenomenon. Clinical presentation One patient with a brain AVM was referred for radiosurgical treatment. Shortly before treatment however, complete spontaneous regression occurred. This patient had experienced a hemorrhage in the months before referral Results We found 38 articles in which 67 cases of complete and spontaneous regression of a brain AVM were presented. Male to female ratio was 1.2, with a mean age of 37 years (range 1–81). Regression occurred in 72% without new neurological events. Median size of the nidus was 2 cm (range 1–7). There was a single arterial feeder in 46% and a single draining vein in 59%. Conclusion Spontaneous regression of a brain AVM is the result of multiple interacting factors. Intracranial hemorrhage and the presence of a single draining vein seem to play a major role in this process.
- Subjects
ARTERIOVENOUS fistula; ANGIOGRAPHY; HEMORRHAGE; INTRACRANIAL hematoma; BRAIN
- Publication
Journal of Neurology, 2004, Vol 251, Issue 11, p1375
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-004-0548-3