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- Title
Amyloid excess in Alzheimer’s disease: What is cholesterol to be blamed for?
- Authors
Ledesma, Maria Dolores; Dotti, Carlos G.
- Abstract
Abstract: A link between alterations in cholesterol homeostasis and Alzheimer’s disease (AD) is nowadays widely accepted. However, the molecular mechanism/s underlying such link remain unclear. Numerous experimental evidences support the view that changes in neuronal membrane cholesterol levels and/or subcellular distribution determine the aberrant accumulation of the amyloid peptide in the disease. Still, this view comes from rather contradictory data supporting the existence of either high or low brain cholesterol content. This is of particular concern considering that therapeutical strategies aimed to reduce cholesterol levels are already being tested in humans. Here, we review the molecular mechanisms proposed and discuss the perspectives they open.
- Subjects
ISOPENTENOIDS; LOW-cholesterol diet; CHOLESTEROL; STEROLS
- Publication
FEBS Letters, 2006, Vol 580, Issue 23, p5525
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.06.038