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- Title
Differential β-arrestin binding of AT<sub>1</sub> and AT<sub>2</sub> angiotensin receptors
- Authors
Turu, Gábor; Szidonya, László; Gáborik, Zsuzsanna; Buday, László; Spät, András; Clark, Adrian J.L.; Hunyady, László
- Abstract
Abstract: Agonist stimulation of G protein-coupled receptors causes receptor activation, phosphorylation, β-arrestin binding and receptor internalization. Angiotensin II (AngII) causes rapid internalization of the AT1 receptors, whereas AngII-bound AT2 receptors do not internalize. Although the activation of the rat AT1A receptor with AngII causes translocation of β-arrestin2 to the receptor, no association of this molecule with the AT2 receptor can be detected after AngII treatment with confocal microscopy or bioluminescence resonance energy transfer. These data demonstrate that the two subtypes of angiotensin receptors have different mechanisms of regulation.
- Subjects
G proteins; ANGIOTENSINS; PROTEIN kinases; CHROMOSOMAL translocation
- Publication
FEBS Letters, 2006, Vol 580, Issue 1, p41
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.11.044