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- Title
Oligo-microarray analysis reveals the role of cyclophilin A in drug resistance.
- Authors
Chen S; Zhang M; Ma H; Saiyin H; Shen S; Xi J; Wan B; Yu L; Chen, Shuai; Zhang, Mingjun; Ma, Honghui; Saiyin, Hexige; Shen, Suqin; Xi, Jiajie; Wan, Bo; Yu, Long
- Abstract
Cyclophilin A (CYPA) belongs to peptidyl prolyl isomerases (PPIases), which catalyze the cis/trans isomerization of prolyl peptide bonds in cellular communication. CYPA has been implicated in several pathological processes, including cancer, inflammatory diseases, and HIV-1 infection. Up-regulation of CYPA has been found to be a common phenomenon in several tumor types, including in hepatocellular carcinoma (HCC). However, the role of CYPA in tumor cells remains unknown. We generated a stable SK-Hep1 cell line and studied the CYPA regulated genes at the transcriptome level. The microarray results reveal that CYPA can up-regulate the expression of many cytokine and drug resistance related genes. Furthermore, we showed that the elevated CYPA expression contributes to drug resistance. We postulate that the over-expression of CYPA in tumors may play a role in clinical resistance to chemotherapy.
- Publication
Cancer Chemotherapy & Pharmacology, 2008, Vol 61, Issue 3, p459
- ISSN
0344-5704
- Publication type
journal article
- DOI
10.1007/s00280-007-0491-y