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- Title
Phase II study of weekly chemotherapy with paclitaxel and gemcitabine as second-line treatment for advanced non-small cell lung cancer after treatment with platinum-based chemotherapy.
- Authors
Mori, Kiyoshi; Kamiyama, Yukari; Kondo, Tetsuro; Kano, Yasuhiko; Kodama, Tetsuro
- Abstract
We evaluated the tolerability and activity of the combination of weekly paclitaxel (PTX) and gemcitabine (GEM) in second-line treatment of advanced non-small cell lung cancer (NSCLC) after treatment with platinum-based chemotherapy. PTX (100 mg/m2) and GEM (1,000 mg/m2) were administered to patients with previous treated NSCLC on days 1 and 8 every 3 weeks. A total of 40 patients (performance status 0/1/2, 7/27/6 pts) were enrolled. The response rate was 32.5% (95% confidence interval: 18.0–47.0%). The median survival time was 41.7 weeks (95% confidence interval: 28.5–54.7 weeks). The median time to disease progression was 19 weeks. Hematological toxicities (grade 3 or 4) observed included neutropenia in 60%, anemia in 15%, and thrombocytopenia in 12.5% of patients. Non-hematological toxicities were mild, with the exception of grade 3 diarrhea, pneumonitis, and rash in one patient each. There were no deaths due to toxicity. The combination of weekly PTX and GEM is a feasible, well-tolerated, and active means of second-line treatment of advanced NSCLC.
- Subjects
CANCER treatment; PACLITAXEL; ANTINEOPLASTIC agents; LUNG cancer; DRUG therapy
- Publication
Cancer Chemotherapy & Pharmacology, 2007, Vol 60, Issue 2, p189
- ISSN
0344-5704
- Publication type
Article
- DOI
10.1007/s00280-006-0360-0