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- Title
Decreased Levels of β-Endorphin in Circulating Mononuclear Leukocytes from Patients with Acute Myocardial Infarction.
- Authors
Buratti, Thomas; Schratzberger, Peter; Dunzendorfer, Stefan; Manfreda, Susanne E.; Pechlaner, Christoph; Joannidis, Michael; Sacerdote, Paula; Panerai, Alberto E.; Wiedermann, Christian J.
- Abstract
Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive β-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of β-endorphin in mononuclear leukocytes of 30.2 ± 6.9 pg/10[sup 6] cells on admission were in the normal range of 20–40 pg/10[sup 6] cells and decreased significantly to 6.9 ± 1.9 pg/10[sup 6] cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated β-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.
- Subjects
ENDORPHINS; CORONARY heart disease treatment; LYMPHOCYTES; INFLAMMATION; BLOOD; OPIOID peptides; MYOCARDIAL infarction; CORONARY disease; OPIOIDS; PSYCHIATRIC drugs
- Publication
Cardiology, 1998, Vol 90, Issue 1, p43
- ISSN
0008-6312
- Publication type
Article
- DOI
10.1159/000006815