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Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants.
Published in:
Frontiers in Aging Neuroscience, 2024, p. 1, doi. 10.3389/fnagi.2024.1447944
By:
- Schalkamp, Ann-Kathrin;
- Lerche, Stefanie;
- Wurster, Isabel;
- Roeben, Benjamin;
- Zimmermann, Milan;
- Fries, Franca;
- von Thaler, Anna-Katharina;
- Eschweiler, Gerhard;
- Maetzler, Walter;
- Berg, Daniela;
- Sinz, Fabian H.;
- Brockmann, Kathrin
Publication type:
Article
Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson's disease and dementia with Lewy bodies.
Published in:
Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01276-6
By:
- Brockmann, Kathrin;
- Quadalti, Corinne;
- Lerche, Stefanie;
- Rossi, Marcello;
- Wurster, Isabel;
- Baiardi, Simone;
- Roeben, Benjamin;
- Mammana, Angela;
- Zimmermann, Milan;
- Hauser, Ann-Kathrin;
- Deuschle, Christian;
- Schulte, Claudia;
- Waniek, Katharina;
- Lachmann, Ingolf;
- Sjödin, Simon;
- Brinkmalm, Ann;
- Blennow, Kaj;
- Zetterberg, Henrik;
- Gasser, Thomas;
- Parchi, Piero
Publication type:
Article
Serum and Cerebrospinal Fluid Uric Acid Levels in Lewy Body Disorders: Associations with Disease Occurrence and Amyloid-β Pathway.
Published in:
Journal of Alzheimer's Disease, 2011, v. 27, n. 1, p. 119, doi. 10.3233/JAD-2011-110587
By:
- Maetzler, Walter;
- Stapf, Anne Kathrin;
- Schulte, Claudia;
- Hauser, Ann-Kathrin;
- Lerche, Stefanie;
- Wurster, Isabel;
- Schleicher, Erwin;
- Melms, Arthur;
- Berg, Daniela
Publication type:
Article
Serum and cerebrospinal fluid uric acid levels in lewy body disorders: associations with disease occurrence and amyloid-β pathway.
Published in:
2011
By:
- Maetzler W;
- Stapf AK;
- Schulte C;
- Hauser AK;
- Lerche S;
- Wurster I;
- Schleicher E;
- Melms A;
- Berg D;
- Maetzler, Walter;
- Stapf, Anne Kathrin;
- Schulte, Claudia;
- Hauser, Ann-Kathrin;
- Lerche, Stefanie;
- Wurster, Isabel;
- Schleicher, Erwin;
- Melms, Arthur;
- Berg, Daniela
Publication type:
journal article
CSF and Serum Levels of Inflammatory Markers in PD: Sparse Correlation, Sex Differences and Association With Neurodegenerative Biomarkers.
Published in:
Frontiers in Neurology, 2022, v. 13, p. 1, doi. 10.3389/fneur.2022.834580
By:
- Lerche, Stefanie;
- Zimmermann, Milan;
- Wurster, Isabel;
- Roeben, Benjamin;
- Fries, Franca Laura;
- Deuschle, Christian;
- Waniek, Katharina;
- Lachmann, Ingolf;
- Gasser, Thomas;
- Jakobi, Meike;
- Joos, Thomas O.;
- Schneiderhan-Marra, Nicole;
- Brockmann, Kathrin
Publication type:
Article
Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.
Published in:
Frontiers in Aging Neuroscience, 2016, p. 1, doi. 10.3389/fnagi.2016.00147
By:
- Heinzel, Sebastian;
- Roeben, Benjamin;
- Ben-Shlomo, Yoav;
- Lerche, Stefanie;
- Alves, Guido;
- Barone, Paolo;
- Behnke, Stefanie;
- Berendse, Henk W.;
- Bloem, Bastiaan R.;
- Burn, David;
- Dodel, Richard;
- Grosset, Donald G.;
- Hu, Michele;
- Kasten, Meike;
- Krüger, Rejko;
- Moccia, Marcello;
- Mollenhauer, Brit;
- Oertel, Wolfgang;
- Suenkel, Ulrike;
- Walter, Uwe
Publication type:
Article
Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies.
Published in:
Frontiers in Aging Neuroscience, 2016, p. 1, doi. 10.3389/fnagi.2016.00121
By:
- Lerche, Stefanie;
- Heinzel, Sebastian;
- Alves, Guido W.;
- Barone, Paolo;
- Behnke, Stefanie;
- Ben-Shlomo, Yoav;
- Berendse, Henk;
- Bloem, Bastiaan R.;
- Burn, David;
- Dodel, Richard;
- Grosset, Donald G.;
- Hipp, Geraldine;
- Hu, Michele T.;
- Kasten, Meike;
- Krüger, Rejko;
- Liepelt-Scarfone, Inga;
- Maetzler, Walter;
- Moccia, Marcello;
- Mollenhauer, Brit;
- Oertel, Wolfgang
Publication type:
Article
Mild Parkinsonian Signs in the Elderly – Is There an Association with PD? Crossectional Findings in 992 Individuals.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0092878
By:
- Lerche, Stefanie;
- Hobert, Markus;
- Brockmann, Kathrin;
- Wurster, Isabel;
- Gaenslen, Alexandra;
- Hasmann, Sandra;
- Eschweiler, Gerhard W.;
- Maetzler, Walter;
- Berg, Daniela
Publication type:
Article
Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.
Published in:
EMBO Journal, 2008, v. 27, n. 2, p. 350, doi. 10.1038/sj.emboj.7601952
By:
- Witt, Christian C.;
- Witt, Stephanie H.;
- Lerche, Stefanie;
- Labeit, Dietmar;
- Back, Walter;
- Labeit, Siegfried
Publication type:
Article
Longitudinal cognitive decline characterizes the profile of non-PD-manifest GBA1 mutation carriers.
Published in:
NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-024-00706-1
By:
- Roeben, Benjamin;
- Liepelt-Scarfone, Inga;
- Lerche, Stefanie;
- Zimmermann, Milan;
- Wurster, Isabel;
- Sünkel, Ulrike;
- Schulte, Claudia;
- Deuschle, Christian;
- Eschweiler, Gerhard W.;
- Maetzler, Walter;
- Gasser, Thomas;
- Berg, Daniela;
- Brockmann, Kathrin
Publication type:
Article
CSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in Parkinson's disease.
Published in:
NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-023-00627-5
By:
- Brockmann, Kathrin;
- Lerche, Stefanie;
- Baiardi, Simone;
- Rossi, Marcello;
- Wurster, Isabel;
- Quadalti, Corinne;
- Roeben, Benjamin;
- Mammana, Angela;
- Zimmermann, Milan;
- Hauser, Ann‑Kathrin;
- Deuschle, Christian;
- Schulte, Claudia;
- Liepelt-Scarfone, Inga;
- Gasser, Thomas;
- Parchi, Piero
Publication type:
Article
Inflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD.
Published in:
NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00476-2
By:
- Lerche, Stefanie;
- Zimmermann, Milan;
- Roeben, Benjamin;
- Wurster, Isabel;
- Fries, Franca Laura;
- Deuschle, Christian;
- Waniek, Katharina;
- Lachmann, Ingolf;
- Jakobi, Meike;
- Joos, Thomas O.;
- Knorpp, Thomas;
- Schneiderhan-Marra, Nicole;
- Brockmann, Kathrin
Publication type:
Article
Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs.
Published in:
Alzheimer's Research & Therapy, 2016, v. 8, p. 1, doi. 10.1186/s13195-016-0209-7
By:
- Lerche, Stefanie;
- Brockmann, Kathrin;
- Wurster, Isabel;
- Sünkel, Ulrike;
- Hobert, Markus A.;
- von Thaler, Anna-Katharina;
- Schulte, Claudia;
- Maetzler, Walter;
- Berg, Daniela;
- Pilotto, Andrea;
- Stoops, Erik;
- Vanderstichele, Hugo;
- Herbst, Victor;
- Brix, Britta;
- Eschweiler, Gerhard W.;
- Metzger, Florian G.
Publication type:
Article
Clinical characteristics related to worsening of motor function assessed by the Unified Parkinson's Disease Rating Scale in the elderly population.
Published in:
Journal of Neurology, 2015, v. 262, n. 2, p. 451, doi. 10.1007/s00415-014-7584-4
By:
- Liepelt-Scarfone, Inga;
- Lerche, Stefanie;
- Behnke, Stefanie;
- Godau, Jana;
- Gaenslen, Alexandra;
- Pausch, Christoph;
- Fassbender, Klaus;
- Brockmann, Kathrin;
- Srulijes, Karin;
- Huber, Heiko;
- Wurster, Isabel;
- Berg, Daniela
Publication type:
Article
Risk factors and prodromal markers and the development of Parkinson's disease.
Published in:
Journal of Neurology, 2014, v. 261, n. 1, p. 180, doi. 10.1007/s00415-013-7171-0
By:
- Lerche, Stefanie;
- Seppi, Klaus;
- Behnke, Stefanie;
- Liepelt-Scarfone, Inga;
- Godau, Jana;
- Mahlknecht, Philipp;
- Gaenslen, Alexandra;
- Brockmann, Kathrin;
- Srulijes, Karin;
- Huber, Heiko;
- Wurster, Isabel;
- Stockner, Heike;
- Kiechl, Stefan;
- Willeit, Johann;
- Gasperi, Arno;
- Fassbender, Klaus;
- Poewe, Werner;
- Berg, Daniela
Publication type:
Article
Association of elevated cerebrospinal fluid levels of the longevity protein α‐Klotho with a delayed onset of cognitive impairment in Parkinson's disease patients.
Published in:
European Journal of Neurology, 2024, v. 31, n. 10, p. 1, doi. 10.1111/ene.16388
By:
- Zimmermann, Milan;
- Fandrich, Madeleine;
- Jakobi, Meike;
- Röben, Benjamin;
- Wurster, Isabel;
- Lerche, Stefanie;
- Schulte, Claudia;
- Zimmermann, Shahrzad;
- Deuschle, Christian;
- Schneiderhan‐Marra, Nicole;
- Gasser, Thomas;
- Brockmann, Kathrin
Publication type:
Article
The longevity gene Klotho and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease.
Published in:
European Journal of Neurology, 2021, v. 28, n. 5, p. 1557, doi. 10.1111/ene.14733
By:
- Zimmermann, Milan;
- Köhler, Leonie;
- Kovarova, Marketa;
- Lerche, Stefanie;
- Schulte, Claudia;
- Wurster, Isabel;
- Machetanz, Gerrit;
- Deuschle, Christian;
- Hauser, Ann‐Kathrin;
- Gasser, Thomas;
- Berg, Daniela;
- Schleicher, Erwin;
- Maetzler, Walter;
- Brockmann, Kathrin
Publication type:
Article
GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and Lewy Body Dementia.
Published in:
PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0149349
By:
- Maetzler, Walter;
- Deleersnijder, Willy;
- Hanssens, Valérie;
- Bernard, Alice;
- Brockmann, Kathrin;
- Marquetand, Justus;
- Wurster, Isabel;
- Rattay, Tim W.;
- Roncoroni, Lorenzo;
- Schaeffer, Eva;
- Lerche, Stefanie;
- Apel, Anja;
- Deuschle, Christian;
- Berg, Daniela
Publication type:
Article
Impact of APOE Genotype on Cognition in Idiopathic and Genetic Forms of Parkinson's Disease.
Published in:
Movement Disorders, 2023, v. 38, n. 5, p. 907, doi. 10.1002/mds.29399
By:
- Koros, Christos;
- Brockmann, Kathrin;
- Simitsi, Athina‐Maria;
- Bougea, Anastasia;
- Liu, Hui;
- Hauser, Ann‐Kathrin;
- Schulte, Claudia;
- Lerche, Stefanie;
- Pachi, Ioanna;
- Papagiannakis, Nikolaos;
- Antonelou, Roubina;
- Zahou, Athina;
- Wurster, Isabel;
- Efthymiopoulou, Efthymia;
- Beratis, Ion;
- Maniati, Matina;
- Moraitou, Marina;
- Michelakakis, Helen;
- Paraskevas, Georgios;
- Papageorgiou, Sokratis G.
Publication type:
Article
CSF Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in PD and DLB.
Published in:
Movement Disorders, 2021, v. 36, n. 11, p. 2595, doi. 10.1002/mds.28704
By:
- Lerche, Stefanie;
- Sjödin, Simon;
- Brinkmalm, Ann;
- Blennow, Kaj;
- Wurster, Isabel;
- Roeben, Benjamin;
- Zimmermann, Milan;
- Hauser, Ann‐Kathrin;
- Liepelt‐Scarfone, Inga;
- Waniek, Katharina;
- Lachmann, Ingolf;
- Gasser, Thomas;
- Zetterberg, Henrik;
- Brockmann, Kathrin
Publication type:
Article
The Mutation Matters: CSF Profiles of GCase, Sphingolipids, α‐Synuclein in PD<sub>GBA</sub>.
Published in:
Movement Disorders, 2021, v. 36, n. 5, p. 1216, doi. 10.1002/mds.28472
By:
- Lerche, Stefanie;
- Schulte, Claudia;
- Wurster, Isabel;
- Machetanz, Gerrit;
- Roeben, Benjamin;
- Zimmermann, Milan;
- Deuschle, Christian;
- Hauser, Ann‐Kathrin;
- Böhringer, Judith;
- Krägeloh‐Mann, Ingeborg;
- Waniek, Katharina;
- Lachmann, Ingolf;
- Petterson, Xuan‐Mai T.;
- Chiang, Ruby;
- Park, Hyejung;
- Wang, Bing;
- Liepelt‐Scarfone, Inga;
- Maetzler, Walter;
- Galasko, Douglas;
- Scherzer, Clemens R.
Publication type:
Article
CSF NFL in a Longitudinally Assessed PD Cohort: Age Effects and Cognitive Trajectories.
Published in:
2020
By:
- Lerche, Stefanie;
- Wurster, Isabel;
- Röben, Benjamin;
- Zimmermann, Milan;
- Machetanz, Gerrit;
- Wiethoff, Sarah;
- Dehnert, Monique;
- Rietschel, Lea;
- Riebenbauer, Benjamin;
- Deuschle, Christian;
- Stransky, Elke;
- Lieplt‐Scarfone, Inga;
- Gasser, Thomas;
- Brockmann, Kathrin;
- Lieplt-Scarfone, Inga
Publication type:
journal article
Parkinson's Disease: Glucocerebrosidase 1 Mutation Severity Is Associated with CSF Alpha-Synuclein Profiles.
Published in:
2020
By:
- Lerche, Stefanie;
- Wurster, Isabel;
- Roeben, Benjamin;
- Zimmermann, Milan;
- Riebenbauer, Benjamin;
- Deuschle, Christian;
- Hauser, Ann‐Kathrin;
- Schulte, Claudia;
- Berg, Daniela;
- Maetzler, Walter;
- Waniek, Katharina;
- Lachmann, Ingolf;
- Liepelt‐Scarfone, Inga;
- Gasser, Thomas;
- Brockmann, Kathrin;
- Hauser, Ann-Kathrin;
- Liepelt-Scarfone, Inga
Publication type:
journal article
Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile.
Published in:
2019
By:
- Lerche, Stefanie;
- Machetanz, Gerrit;
- Wurster, Isabel;
- Roeben, Benjamin;
- Zimmermann, Milan;
- Pilotto, Andrea;
- Preische, Oliver;
- Stransky, Elke;
- Deuschle, Christian;
- Hauser, Ann‐Kathrin;
- Schulte, Claudia;
- Lachmann, Ingolf;
- Waniek, Katharina;
- Gasser, Thomas;
- Berg, Daniela;
- Maetzler, Walter;
- Brockmann, Kathrin;
- Hauser, Ann-Kathrin
Publication type:
journal article
Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease - Report of the JPND Working Group BioLoC-PD.
Published in:
Neuroepidemiology, 2015, v. 45, n. 4, p. 282, doi. 10.1159/000439221
By:
- Lerche, Stefanie;
- Liepelt-Scarfone, Inga;
- alves, Guido;
- Barone, Paolo;
- Behnke, Stefanie;
- Ben-Shlomo, Yoav;
- Berendse, Henk;
- Burn, David;
- Dodel, Richard;
- Grosset, Donald;
- Heinzel, Sebastian;
- Hu, Michele;
- Kasten, Meike;
- Krüger, Rejko;
- Maetzler, Walter;
- Moccia, Marcello;
- Mollenhauer, Brit;
- Oertel, Wolfgang;
- Roeben, Benjamin;
- Sünkel, Ulrike
Publication type:
Article
Polygenic load: Earlier disease onset but similar longitudinal progression in Parkinson's disease.
Published in:
2018
By:
- Lerche, Stefanie;
- Liepelt‐Scarfone, Inga;
- Wurster, Isabel;
- Schulte, Claudia;
- Schäffer, Eva;
- Röben, Benjamin;
- Machetanz, Gerrit;
- Zimmermann, Milan;
- Akbas, Selda;
- Hauser, Ann‐Kathrin;
- Gasser, Thomas;
- Maetzler, Walter;
- Berg, Daniela;
- Brockmann, Kathrin;
- Liepelt-Scarfone, Inga;
- Hauser, Ann-Kathrin
Publication type:
journal article
Cognitive impairment in Glucocerebrosidase (GBA)‐associated PD: Not primarily associated with cerebrospinal fluid Abeta and Tau profiles.
Published in:
Movement Disorders, 2017, v. 32, n. 12, p. 1780, doi. 10.1002/mds.27199
By:
- Lerche, Stefanie;
- Schulte, Claudia;
- Srulijes, Karin;
- Pilotto, Andrea;
- Rattay, Tim W.;
- Hauser, Ann‐Kathrin;
- Stransky, Elke;
- Deuschle, Christian;
- Csoti, Ilona;
- Lachmann, Ingolf;
- Zetterberg, Henrik;
- Liepelt‐Scarfone, Inga;
- Gasser, Thomas;
- Maetzler, Walter;
- Berg, Daniela;
- Brockmann, Kathrin
Publication type:
Article
Application of the movement disorder society prodromal Parkinson's disease research criteria in 2 independent prospective cohorts.
Published in:
2017
By:
- Pilotto, Andrea;
- Heinzel, Sebastian;
- Suenkel, Ulrike;
- Lerche, Stefanie;
- Brockmann, Kathrin;
- Roeben, Benjamin;
- Schaeffer, Eva;
- Wurster, Isabel;
- Yilmaz, Rezzak;
- Liepelt‐Scarfone, Inga;
- Thaler, Anna‐Katharina;
- Metzger, Florian G.;
- Eschweiler, Gerhard W.;
- Postuma, Ron B.;
- Maetzler, Walter;
- Berg, Daniela
Publication type:
journal article
Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's disease.
Published in:
Movement Disorders, 2013, v. 28, n. 2, p. 216, doi. 10.1002/mds.25192
By:
- Berg, Daniela;
- Behnke, Stefanie;
- Seppi, Klaus;
- Godau, Jana;
- Lerche, Stefanie;
- Mahlknecht, Philipp;
- Liepelt‐Scarfone, Inga;
- Pausch, Christoph;
- Schneider, Niko;
- Gaenslen, Alexandra;
- Brockmann, Kathrin;
- Srulijes, Karin;
- Huber, Heiko;
- Wurster, Isabel;
- Stockner, Heike;
- Kiechl, Stefan;
- Willeit, Johann;
- Gasperi, Arno;
- Fassbender, Klaus;
- Gasser, Thomas
Publication type:
Article
CSF d18:1 sphingolipid species in Parkinson disease and dementia with Lewy bodies with and without GBA1 variants.
Published in:
NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-024-00820-0
By:
- Lerche, Stefanie;
- Wurster, Isabel;
- Valente, Enza Maria;
- Avenali, Micol;
- Samaniego, Daniela;
- Martínez-Vicente, Marta;
- Hernández-Vara, Jorge;
- Laguna, Ariadna;
- Sturchio, Andrea;
- Svenningsson, Per;
- France, Nicholas P.;
- Barlow, Carrolee;
- Sankaranarayanan, Sethu;
- Brockmann, Kathrin
Publication type:
Article

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