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- Title
The structure and functions of paxillin and its roles in neovascularization.
- Authors
YANG, W.-J.; ZHONG, J.; YU, J.-G.; ZHAO, F.; XIANG, Y.
- Abstract
Identifying and studying the molecular mechanisms of neovascularization biomarkers are critical for conquering many diseases, such as corneal diseases and cancer. Paxillin is an important cell scaffold and cellular signaling protein, especially a key molecule of the Integrin-mediated downstream signaling transduction. This review summarizes the structure and functions of paxillin, and the research progress of its roles in neovascularization. Although there are still some problems to be solved, paxillin may become an important target of anti-neovascularization therapies.
- Subjects
PAXILLIN; NEOVASCULARIZATION; INTEGRINS; VASCULAR endothelial growth factors; BLOOD-vessel development
- Publication
European Review for Medical & Pharmacological Sciences, 2017, Vol 21, Issue 8, p1768
- ISSN
1128-3602
- Publication type
Article