We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of caspofungin (MK-0991) and anidulafungin (LY303366) on phagocytosis, oxidative burst and killing ofCandida albicansby human phagocytes.
- Authors
Frank, U.; Greiner, M.; Engels, I.; Daschner, F. D.
- Abstract
The objective of the present study was to investigate the influence of the new echinocandins caspofungin (MK-0991) and anidulafungin (LY303366) on human phagocytes. Phagocytosis, oxidative burst and intracellular killing ofCandida albicanswere analyzed by flow cytometry. Neither caspofungin nor anidulafungin significantly influenced phagocytosis. Only caspofungin significantly influenced oxidative burst after 15 min of incubation (P<0.05). Both caspofungin and anidulafungin improved intracellular killing rates ofC. albicansafter 2 h of incubation (42.4% and 43.2%, respectively, compared to 37.9% in controls;P<0.05). In conclusion, caspofungin significantly improves oxidative burst and intracellular killing, which may be advantageous for clinical therapy.
- Subjects
PHAGOCYTOSIS; IMMUNE response; PHAGOCYTES; CANDIDA albicans; FLOW cytometry
- Publication
European Journal of Clinical Microbiology & Infectious Diseases, 2004, Vol 23, Issue 9, p729
- ISSN
0934-9723
- Publication type
Article
- DOI
10.1007/s10096-004-1171-z