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- Title
Chronic Opisthorchis viverrini Infection and Associated Hepatobiliary Disease Is Associated with Iron Loaded M2-like Macrophages.
- Authors
Bility, Moses T.; Sripa, Banchob
- Abstract
Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.
- Subjects
OPISTHORCHIS viverrini; MACROPHAGES; LEUCOCYTES; GENE expression; HAMSTERS
- Publication
Korean Journal of Parasitology, 2014, Vol 52, Issue 6, p695
- ISSN
0023-4001
- Publication type
Article
- DOI
10.3347/kjp.2014.52.6.695