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Stimulation of Naïve Monocytes and PBMCs with Coagulation Proteases Results in Thrombin-Mediated and PAR-1-Dependent Cytokine Release and Cell Proliferation in PBMCs Only.
Published in:
Scandinavian Journal of Immunology, 2013, v. 77, n. 5, p. 339, doi. 10.1111/sji.12033
By:
- Nieuwenhuizen, L.;
- Falkenburg, W. J. J.;
- Schutgens, R. E. G.;
- Roosendaal, G.;
- Veghel, K.;
- Biesma, D. H.;
- Lafeber, F. P. J. G.
Publication type:
Article
Prevalence, burden and treatment effects of vaginal bleeding in women with (suspected) congenital platelet disorders throughout life: a cross‐sectional study.
Published in:
British Journal of Haematology, 2022, v. 196, n. 1, p. 215, doi. 10.1111/bjh.17791
By:
- Punt, Marieke C.;
- Ruigrok, Nienke D.;
- Bloemenkamp, Kitty W. M.;
- Uitslager, Nanda;
- Urbanus, Rolf T.;
- Groot, Evelyn;
- Kremer Hovinga, Idske C. L.;
- Schutgens, Roger E. G.;
- van Galen, Karin P. M.;
- Kruip, M. J. H. A.;
- Beckers, E. A. M.;
- Coppens, M.;
- Eikenboom, J.;
- van Galen, K. P. M.;
- Tamminga, R. Y. J.;
- Urbanus, R. T.;
- Schutgens, R. E. G.
Publication type:
Article
Application of SHAP values for inferring the optimal functional form of covariates in pharmacokinetic modeling.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 8, p. 1100, doi. 10.1002/psp4.12828
By:
- Janssen, Alexander;
- Hoogendoorn, Mark;
- Cnossen, Marjon H.;
- Mathôt, Ron A. A.;
- Cnossen, M. H.;
- Reitsma, S. H.;
- Leebeek, F. W. G.;
- Mathôt, R. A. A.;
- Fijnvandraat, K.;
- Coppens, M.;
- Meijer, K.;
- Schols, S. E. M.;
- Eikenboom, H. C. J.;
- Schutgens, R. E. G.;
- Beckers, E. A. M.;
- Ypma, P.;
- Kruip, M. J. H. A.;
- Polinder, S.;
- Tamminga, R. Y. J.;
- Brons, P.
Publication type:
Article
Deep compartment models: A deep learning approach for the reliable prediction of time‐series data in pharmacokinetic modeling.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 7, p. 934, doi. 10.1002/psp4.12808
By:
- Janssen, Alexander;
- Leebeek, Frank W. G.;
- Cnossen, Marjon H.;
- Mathôt, Ron A. A.;
- Fijnvandraat, K.;
- Coppens, M.;
- Meijer, K.;
- Schols, S. E. M.;
- Eikenboom, H. C. J.;
- Schutgens, R. E. G.;
- Beckers, E. A. M.;
- Ypma, P.;
- Kruip, M. J. H. A.;
- Polinder, S.;
- Tamminga, R. Y. J.;
- Brons, P.;
- Fischer, K.;
- van Galen, K. P. M.;
- Nieuwenhuizen, L.;
- Driessens, M. H. E.
Publication type:
Article
Continuous infusion of extended half‐life factor VIII (efmoroctocog alpha) for surgery in severe haemophilia A.
Published in:
Haemophilia, 2018, v. 24, n. 4, p. e280, doi. 10.1111/hae.13557
By:
- Kremer Hovinga, I. C. L.;
- Schutgens, R. E. G.;
- van der Valk, P. R.;
- van Vulpen, L. F. D.;
- Mauser‐Bunschoten, E. P.;
- Fischer, K.
Publication type:
Article
The combination of urinary CTX‐II and serum CS‐846: Promising biochemical markers to predict radiographic progression of haemophilic arthropathy—An exploratory study.
Published in:
Haemophilia, 2018, v. 24, n. 4, p. e278, doi. 10.1111/hae.13554
By:
- Pulles, A. E.;
- Mastbergen, S. C.;
- Foppen, W.;
- Schutgens, R. E. G.;
- Lafeber, F. P. J. G.;
- van Vulpen, L. F. D.
Publication type:
Article
Movement behaviour in adults with haemophilia compared to healthy adults.
Published in:
Haemophilia, 2018, v. 24, n. 3, p. 445, doi. 10.1111/hae.13441
By:
- Schutgens, R. E. G.;
- Timmer, M. A.;
- de Kleijn, P.;
- Veenhof, C.;
- Pisters, M. F.;
- de Bie, R. A.
Publication type:
Article
Measuring activities and participation in persons with haemophilia: A systematic review of commonly used instruments.
Published in:
Haemophilia, 2018, v. 24, n. 2, p. e33, doi. 10.1111/hae.13367
By:
- Schutgens, R. E. G.;
- Fischer, K.;
- Timmer, M. A.;
- de Kleijn, P.;
- Pisters, M. F.;
- Gouw, S. C.;
- Zwagemaker, A.;
- Feldman, B. M.;
- Blanchette, V.;
- Srivastava, A.;
- David, J. A.;
- van der Net, J.
Publication type:
Article
Differential effects of bleeds on the development of arthropathy - basic and applied issues.
Published in:
Haemophilia, 2017, v. 23, n. 4, p. 521, doi. 10.1111/hae.13236
By:
- Vulpen, L. F. D.;
- Mastbergen, S. C.;
- Lafeber, F. P. J. G.;
- Schutgens, R. E. G.
Publication type:
Article
Comparing findings of routine Haemophilia Joint Health Score and Haemophlia Early Arthropathy Detection with UltraSound assessments in adults with haemophilia.
Published in:
Haemophilia, 2017, v. 23, n. 2, p. e141, doi. 10.1111/hae.13147
By:
- Timmer, M. A.;
- Foppen, W.;
- Schutgens, R. E. G.;
- Pisters, M. F.;
- Fischer, K.
Publication type:
Article
Long-term effects of joint bleeding before starting prophylaxis in severe haemophilia.
Published in:
Haemophilia, 2016, v. 22, n. 6, p. 852, doi. 10.1111/hae.12959
By:
- Nijdam, A.;
- Foppen, W.;
- Schouw, Y. T.;
- Mauser‐Bunschoten, E. P.;
- Schutgens, R. E. G.;
- Fischer, K.
Publication type:
Article
First preclinical support for the 'danger theory' in inhibitor development.
Published in:
Haemophilia, 2016, v. 22, n. 5, p. 654, doi. 10.1111/hae.13042
By:
- Vulpen, L. F. D.;
- Mastbergen, S. C.;
- Schutgens, R. E. G.
Publication type:
Article
How do patients and professionals differentiate between intra-articular joint bleeds and acute flare-ups of arthropathy in patients with haemophilia?
Published in:
Haemophilia, 2016, v. 22, n. 3, p. 368, doi. 10.1111/hae.12858
By:
- Timmer, M. A.;
- Pisters, M. F.;
- Kleijn, P.;
- Veenhof, C.;
- Laros‐van Gorkom, B. A. P.;
- Kruip, M. J. H. A.;
- Bie, R. A.;
- Schutgens, R. E. G.
Publication type:
Article
Joint surgery in von Willebrand disease: a multicentre cross-sectional study.
Published in:
Haemophilia, 2016, v. 22, n. 2, p. 256, doi. 10.1111/hae.12834
By:
- Galen, K. P. M.;
- Meijer, K.;
- Vogely, H. C.;
- Eikenboom, J.;
- Schutgens, R. E. G.;
- Cnossen, M. H.;
- Fijnvandraat, K.;
- Bom, J. G.;
- Laros‐van Gorkom, B. A. P.;
- Leebeek, F. W. G.;
- Mauser‐Bunschoten, E. P.
Publication type:
Article
A patient with severe haemophilia A and multiple arterial thromboses caused by large vessel vasculitis: a case report.
Published in:
Haemophilia, 2016, v. 22, n. 1, p. e39, doi. 10.1111/hae.12787
By:
- Vos, L. M.;
- Schutgens, R. E. G.;
- Valk, H. W.;
- Spiering, W.;
- Bemelmans, R. H. H.
Publication type:
Article
Silencing of protease-activated receptors attenuates synovitis and cartilage damage following a joint bleed in haemophilic mice.
Published in:
Haemophilia, 2016, v. 22, n. 1, p. 152, doi. 10.1111/hae.12770
By:
- Nieuwenhuizen, L.;
- Schutgens, R. E. G.;
- Coeleveld, K.;
- Mastbergen, S. C.;
- Schiffelers, R. M.;
- Roosendaal, G.;
- Biesma, D. H.;
- Lafeber, F. P. J. G.
Publication type:
Article
Thalidomide for treatment of gastrointestinal bleedings due to angiodysplasia: a case report in acquired von Willebrand syndrome and review of the literature.
Published in:
Haemophilia, 2015, v. 21, n. 4, p. 419, doi. 10.1111/hae.12701
By:
- Engelen, E. T.;
- Galen, K. P. M.;
- Schutgens, R. E. G.
Publication type:
Article
Joint bleeds in von Willebrand disease patients have significant impact on quality of life and joint integrity: a cross-sectional study.
Published in:
Haemophilia, 2015, v. 21, n. 3, p. e185, doi. 10.1111/hae.12670
By:
- Galen, K. P. M.;
- Sanders, Y. V.;
- Vojinovic, U.;
- Eikenboom, J.;
- Cnossen, M. H.;
- Schutgens, R. E. G.;
- Bom, J. G.;
- Fijnvandraat, K.;
- Laros‐Van Gorkom, B. A. P.;
- Meijer, K.;
- Leebeek, F. W. G.;
- Mauser‐Bunschoten, E. P.
Publication type:
Article
Continuous infusion of recombinant factor VIII formulated with sucrose in surgery: Non-interventional, observational study in patients with severe haemophilia A.
Published in:
Haemophilia, 2015, v. 21, n. 1, p. e19, doi. 10.1111/hae.12530
By:
- Meijer, K.;
- Rauchensteiner, S.;
- Santagostino, E.;
- Platokouki, H.;
- Schutgens, R. E. G.;
- Brunn, M.;
- Tueckmantel, C.;
- Valeri, F.;
- Schinco, P. C.
Publication type:
Article
Management of atrial fibrillation in people with haemophilia – a consensus view by the ADVANCE Working Group.
Published in:
Haemophilia, 2014, v. 20, n. 6, p. e417, doi. 10.1111/hae.12525
By:
- SCHUTGENS, R. E. G.;
- KLAMROTH, R.;
- PABINGER, I.;
- DOLAN, G.
Publication type:
Article
Factor VIII concentrate infusion in patients with haemophilia results in decreased von Willebrand factor and ADAMTS-13 activity.
Published in:
Haemophilia, 2014, v. 20, n. 1, p. 92, doi. 10.1111/hae.12266
By:
- Bladel, E. R.;
- Tuinenburg, A.;
- Roest, M.;
- Groot, P. G.;
- Schutgens, R. E. G.
Publication type:
Article
Cataract surgery in haemophilia.
Published in:
Haemophilia, 2013, v. 19, n. 6, p. e371, doi. 10.1111/hae.12212
By:
- Mauser‐Bunschoten, E. P.;
- Bijlsma, W.;
- Roosendaal, G.;
- Schutgens, R. E. G.
Publication type:
Article
Obesity in haemophilia patients: effect on bleeding frequency, clotting factor concentrate usage, and haemostatic and fibrinolytic parameters.
Published in:
Haemophilia, 2013, v. 19, n. 5, p. 744, doi. 10.1111/hae.12182
By:
- Tuinenburg, A.;
- Biere‐Rafi, S.;
- Peters, M.;
- Verhamme, P.;
- Peerlinck, K.;
- Kruip, M. J. H. A.;
- Gorkom, B. A. P.;
- Roest, M.;
- Meijers, J. C. M.;
- Kamphuisen, P. W.;
- Schutgens, R. E. G.
Publication type:
Article
Cardiac catheterization and intervention in haemophilia patients: prospective evaluation of the 2009 institutional guideline.
Published in:
Haemophilia, 2013, v. 19, n. 3, p. 370, doi. 10.1111/hae.12109
By:
- Tuinenburg, A.;
- Damen, S. A. J.;
- Ypma, P. F.;
- Mauser‐Bunschoten, E. P.;
- Voskuil, M.;
- Schutgens, R. E. G.
Publication type:
Article
Risk of inhibitor development in mild haemophilia A increases with age.
Published in:
Haemophilia, 2012, v. 18, n. 2, p. 263, doi. 10.1111/j.1365-2516.2011.02629.x
By:
- MAUSER-BUNSCHOTEN, E. P.;
- DEN UIJL, I. E. M;
- SCHUTGENS, R. E. G;
- ROOSENDAAL, G.;
- FISCHER, K.
Publication type:
Article
Does haemophilia protect against ischaemic cardiovascular disease?
Published in:
Haemophilia, 2012, v. 18, n. 1, p. e35, doi. 10.1111/j.1365-2516.2011.02684.x
By:
- FRANSEN VAN DE PUTTE, D. E.;
- FISCHER, K.;
- SCHUTGENS, R. E. G.;
- MAUSER-BUNSCHOTEN, E. P.
Publication type:
Article
Clinical severity of haemophilia A: does the classification of the 1950s still stand?
Published in:
Haemophilia, 2011, v. 17, n. 6, p. 849, doi. 10.1111/j.1365-2516.2011.02539.x
By:
- Den UIJL, I. E. M.;
- MAUSER BUNSCHOTEN, E. P.;
- ROOSENDAAL, G.;
- SCHUTGENS, R. E. G.;
- BIESMA, D. H.;
- GROBBEE, D. E.;
- FISCHER, K.
Publication type:
Article
Treatment of ischaemic heart disease in haemophilia patients: an institutional guideline.
Published in:
Haemophilia, 2009, v. 15, n. 4, p. 952, doi. 10.1111/j.1365-2516.2009.02020.x
By:
- SCHUTGENS, R. E. G.;
- TUINENBURG, A.;
- ROOSENDAAL, G.;
- GUYOMI, S. Hoseyni;
- MAUSER-BUNSCHOTEN, E. P.
Publication type:
Article
Co-morbidity in the ageing haemophilia patient: the down side of increased life expectancy.
Published in:
Haemophilia, 2009, v. 15, n. 4, p. 853, doi. 10.1111/j.1365-2516.2009.01987.x
By:
- MAUSER-BUNSCHOTEN, E. P.;
- FRANSEN VAN DE PUTTE, D. E.;
- SCHUTGENS, R. E. G.
Publication type:
Article
Challenges and controversies in haemophilia care in adulthood.
Published in:
Haemophilia, 2009, v. 15, p. 20, doi. 10.1111/j.1365-2516.2008.01949.x
By:
- Dolan, G.;
- Hermans, C.;
- Klamroth, R.;
- Madhok, R.;
- Schutgens, R. E. G.;
- Spengler, U.
Publication type:
Article
A feasibility study on two tailored interventions to improve adherence in adults with haemophilia.
Published in:
Pilot & Feasibility Studies, 2020, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40814-020-00723-w
By:
- Hoefnagels, J. W.;
- Fischer, K.;
- Bos, R. A. T.;
- Driessens, M. H. E.;
- Meijer, S. L. A.;
- Schutgens, R. E. G.;
- Schrijvers, L. H.
Publication type:
Article

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