We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load.
- Authors
Gonçalves, Antonio; Bertrand, Julie; Ke, Ruian; Comets, Emmanuelle; Lamballerie, Xavier; Malvy, Denis; Pizzorno, Andrés; Terrier, Olivier; Rosa Calatrava, Manuel; Mentré, France; Smith, Patrick; Perelson, Alan S.; Guedj, Jérémie
- Abstract
We modeled the viral dynamics of 13 untreated patients infected with severe acute respiratory syndrome‐coronavirus 2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than two logs, drug efficacy needs to be > 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 6–87% efficacy. They may help control virus if administered very early, but may not have a major effect in severely ill patients.
- Subjects
VIRAL load; SARS-CoV-2; DRUG efficacy; PEAK load; TREATMENT effectiveness
- Publication
CPT: Pharmacometrics & Systems Pharmacology, 2020, Vol 9, Issue 9, p509
- ISSN
2163-8306
- Publication type
Article
- DOI
10.1002/psp4.12543