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- Title
Synthesis, X-Ray Crystallography and Leishmanicidal Activity of Benzimidazolinyl Piperidine derivative.
- Authors
Saied Saify, Zafar; Zarreen Mallick, Tabinda; Begum, Nasreen; Yousuf, Samar; Ghufran Saeed, Syed Muhammad; Haider, Shazia; Ashraf, Seema; Qaiser, Shama
- Abstract
Protozoan parasites of the Leishmania genus are the main cause of vector-borne disease leishmaniasis throughout the world. It is caused by at least 17 different species of protozoan Leishmania and transmitted by the bite of infected sand flies. Leishmaniasis could be fatal. Present drugs have limitations to cure it due to the development of drug resistance. Hence, to design an effective leishmanicidal agent would be of great interest. Benzimidazolinyl piperidine has served as potential target due to a vast range of biological activities. In the present study a new 4-(2-keto-1-benzimidazolinyl)piperidine derivative, 1-(2-(4-fluorophenyl)-2-oxoethyl)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidinium bromide has been synthesized and characterized by X-ray crystallography, 1D and 2D NMR spectroscopy. Evaluation by in vitro leishmanicidal assay showed good activity.
- Subjects
CHEMICAL synthesis; PIPERIDINE derivatives; HETEROCYCLIC compounds synthesis; X-ray crystallography; LEISHMANIA; LEISHMANIASIS
- Publication
Journal of the Chemical Society of Pakistan, 2014, Vol 36, Issue 6, p1145
- ISSN
0253-5106
- Publication type
Article