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- Title
In vitro study of IgG production and concanavalin A induced suppressor cell function in acute and chronic hepatitis B virus infection.
- Authors
Nouri-Aria, Kayhan T.; Alexande, G. J. M.; Portmann, B.; Verganl, D.; Eddleston, A. L. W. F.; Williams, R.
- Abstract
To investigate the relationship between liver damage and immune regulation in hepatitis B virus (HBV) infection, 68 patients with HBsAg in serum and a spectrum of liver damage have been studied and compared with 25 controls. In HBsAg carriers, spontaneous IgG production was elevated only in those with chronic active hepatitis (P<0.05) whilst those with less severe inflammation had values comparable to normals. Concanavalin A (Con A) induced suppressor cell regulation of IgG producing cells was impaired in those with chronic active hepatitis (P<0.01) and those with chronic persistent hepatitis (P = 0.05) and there was a correlation in both groups of patients with the severity of portal tract inflammation (P<0.05). In contrast those with minimal liver damage had values in the normal range. Patients presenting with acute hepatitis B also had elevated spontaneous IgG production (P<0.01) and impaired Con A induced suppressor cell regulation of IgG production (P<0.01). Sequential study of three patients prior to the detection of HBsAg in serum and subsequently during and after acute hepatitis B showed that such abnormalities were transient and closely related to the onset of liver damage.
- Subjects
IMMUNOGLOBULIN G; LIVER diseases; HEPATITIS; BILIARY tract; INFLAMMATION; T cells; VIRAL hepatitis
- Publication
Clinical & Experimental Immunology, 1986, Vol 64, Issue 1, p50
- ISSN
0009-9104
- Publication type
Article