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- Title
AtNFXL1, an Arabidopsis homologue of the human transcription factor NF-X1, functions as a negative regulator of the trichothecene phytotoxin-induced defense response.
- Authors
Asano, Tomoya; Masuda, Daisuke; Yasuda, Michiko; Nakashita, Hideo; Kudo, Toshiaki; Kimura, Makoto; Yamaguchi, Kazuo; Nishiuchi, Takumi
- Abstract
Trichothecenes are a closely related family of phytotoxins that are produced by phytopathogenic fungi. In Arabidopsis, expression of AtNFXL1, a homologue of the putative human transcription repressor NF-X1, was significantly induced by application of type A trichothecenes, such as T-2 toxin. An atnfxl1 mutant growing on medium lacking trichothecenes showed no phenotype, whereas a hypersensitivity phenotype was observed in T-2 toxin-treated atnfxl1 mutant plants. Microarray analysis indicated that several defense-related genes (i.e. WRKYs, NBS-LRRs, EDS5, ICS1, etc.) were upregulated in T-2 toxin-treated atnfxl1 mutants compared with wild-type plants. In addition, enhanced salicylic acid (SA) accumulation was observed in T-2 toxin-treated atnfxl1 mutants, which suggests that AtNFXL1 functions as a negative regulator of these defense-related genes via an SA-dependent signaling pathway. We also found that expression of AtNFXL1 was induced by SA and flg22 treatment. Moreover, the atnfxl1 mutant was less susceptible to a compatible phytopathogen, Pseudomonas syringae pv. tomato strain DC3000 ( Pst DC3000). Taken together, these results indicate that AtNFXL1 plays an important role in the trichothecene response, as well as the general defense response in Arabidopsis.
- Subjects
TRANSCRIPTION factors; PHYTOPATHOGENIC fungi; PHYTOPATHOGENIC microorganisms; PARASITIC plants; ARABIDOPSIS; GENOTYPE-environment interaction; SALICYLIC acid
- Publication
Plant Journal, 2008, Vol 53, Issue 3, p450
- ISSN
0960-7412
- Publication type
Article
- DOI
10.1111/j.1365-313X.2007.03353.x