We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of Bisphosphonate on the Endochondral Bone Formation of the Mandibular Condyle.
- Authors
KIM, M. S.; JUNG, S. Y.; KANG, J. H.; KIM, H. J.; KO, H. M.; JUNG, J. Y.; KOH, J. T.; KIM, W. J.; KIM, S. M.; LEE, E. J.; KIM, S. H.
- Abstract
The development of the mandibular condylar cartilage is important for the overall growth of the mandible. However, there have been a few researches into medical approaches aimed at controlling condylar growth. This study examined the effects of bisphosphonate on the growth of the condylar cartilage. Alendronate (3.5 mg/kg/week) was administered to postnatal day 1 SD rats for 7 and 10 days. The thickness of each chondrocyte layer and the level of MMP-9 expression were measured. The anteroposterior diameter of the developing condyle was unaffected by the alendronate treatment for 7 days ( P > 0.05). The total thickness of the cartilage layers was also unaffected by the treatment for 7 days ( P > 0.05). In particular, there was no change in the thickness of the perichondrium and reserve cell layer at the measured condylar regions ( P > 0.05). However, the thickness of the proliferating cell layer was reduced significantly, whereas the thickness of hypertrophied cartilage layer was increased ( P < 0.05). The number of chondroclasts engaged in hypertrophied cartilage resorption was reduced significantly by the alendronate treatment ( P < 0.05). The level of MMP-9 expression was reduced at both the transcription and translation levels by the alendronate treatment for 7 and 10 days. These results indicate that alendronate (>3.5 mg/kg/week) inhibits the longitudinal growth of the mandibular condyle by inhibiting chondrocyte proliferation and the resorption of hypertrophied cartilage for ossification.
- Subjects
CARTILAGE; LIGAMENTS; CONNECTIVE tissues; JAWS; MURIDAE
- Publication
Anatomia, Histologia, Embryologia: Journal of Veterinary Medicine Series C, 2009, Vol 38, Issue 5, p321
- ISSN
0340-2096
- Publication type
Article
- DOI
10.1111/j.1439-0264.2009.00938.x