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- Title
Epidermotropic CD8+ cytotoxic T-cell lymphoma exhibiting a transition from the indolent to the aggressive phase, accompanied by emergence of CD7+ cells and formation of neutrophilic pustules.
- Authors
Ito, Y.; Goto, M.; Hatano, Y.; Kawamoto, M.; Ohishi, M.; Takayasu, S.; Katagiri, K.; Fujiwara, S.
- Abstract
Summary A 47-year-old-man presented with rashes on his trunk and limbs, and a diagnosis of parapsoriasis was made. Ten years later, the rashes had progressed gradually to form plaques and tumours. Gene rearrangement studies revealed monoclonality of the T-cell receptor β-chain (TCR-Jβ)1 gene, and results of flow cytometry and immunohistochemical examination confirmed a diagnosis of epidermotropic CD8+ cytotoxic T-cell lymphoma. The clinical course of the disease remained indolent for some time, but about 2 years later, neutrophilic pustules formed on the surface of the skin lesions, and tumours developed in the patient's testes. Using flow cytometry, emergence of CD7+ cells was found. The patient died the following year of respiratory failure due to brain herniation. On postmortem examination, CD8+ tumour cells were found in the brain. This case demonstrates an unusually protracted indolent phase in a patient with cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma; its transition into the aggressive phase was accompanied by emergence of CD7+ cells and formation of neutrophilic pustules.
- Subjects
CASE studies; QUALITATIVE research; T-cell lymphoma; MALIGNANT pustule; T-cell receptor genes; CYTOMETRY; HERNIA; CANCER cells
- Publication
Clinical & Experimental Dermatology, 2012, Vol 37, Issue 2, p128
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.2011.04160.x