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- Title
Prolonged Survival of Implanting Rat Blastocysts in the Uterus of Congenitally Athymic Mice.
- Authors
Håkansson, S.; Lundkvist, Ö.; Nilsson, O.; Alm, G.
- Abstract
Rat blastocysts were transferred to the uteri of either immunodeficient, congenitally athymic (nu/nu) 'nude' mice or immunocompetent, heterozygous (nu/+) mice. Histological analysis showed that there was a similar frequency to nude athymic mice outlived those in heterozygous controls by at least 3 days, and that blastocysts in nude mice showed delayed and abnormal development and were eventually rejected. These finding suggest that the T-cell deficiency in nude mice may prolong the survival of implanting blastocyst but that other immune or non-immune factors still limit their development.
- Subjects
BLASTOCYST; RODENTS; MAMMALS; IMMUNOCOMPETENT cells; IMMUNE system
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 8, p817
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb02155.x