We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Venomous Secretions from Marine Snails of the Terebridae Family Target Acetylcholine Receptors.
- Authors
Kendel, Yvonne; Melaun, Christian; Kurz, Alexander; Nicke, Annette; Peigneur, Steve; Tytgat, Jan; Wunder, Cora; Mebs, Dietrich; Kauferstein, Silke
- Abstract
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects of venom and gland extracts from three species of the superfamily Terebridae. By 2-electrode voltage-clamp technique the gland extracts were tested on Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) of rat neuronal (α3β2,α3β4,α4β2,α4β4,α7) and muscle subtypes (α1β1γδ), and expressing potassium (Kv1.2 and Kv1.3) and sodium channels (Nav1.2, 1.3, 1.4, 1.6). The extracts were shown to exhibit remarkably high inhibitory activities on almost all nAChRs tested, in particular on the α7 subtype suggesting the presence of peptides of the A-superfamily from the venom of Conus species. In contrast, no effects on the potassium and sodium channels tested were observed. The venoms of terebrid snails may offer an additional source of novel biologically active peptides.
- Subjects
NEOGASTROPODA; GASTROPODA; FRESHWATER animals; POISONOUS animals; ANTIVENINS; NEUROTRANSMITTER receptors
- Publication
Toxins, 2013, Vol 5, Issue 5, p1043
- ISSN
2072-6651
- Publication type
Article
- DOI
10.3390/toxins5051043