We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Vasodilatation and the discovery of endothelium-derived relaxing factor.
- Authors
Angus, J A; Cocks, T M
- Abstract
Whether endothelium-derived relaxing factor (EDRF) is important in the physiology and pathology of vascular reactivity must await the discovery of the nature of the factor and an appropriate antagonist substance. Nevertheless the demonstration that EDRF is powerful, short-lived and can be released by a wide variety of stimuli adds a new dimension to our knowledge of the control of the circulation. The macroenvironment of the vessel wall is influenced by nerves, blood-borne factors and the architecture of the wall. The discovery of a role of the endothelial cell has for the first time forced pharmacologists to consider cell-cell interactions in the micro-environment of the blood-vessel wall. This is a potentially important target for new therapy.
- Subjects
RESEARCH; ENDOTHELIUM; SMOOTH muscle; CELL culture; BLOOD vessels; ANIMAL experimentation; RESEARCH methodology; CELL receptors; EVALUATION research; MEDICAL cooperation; VASODILATION; ACETYLCHOLINE; COMPARATIVE studies; VASODILATORS; ARTERIOSCLEROSIS; CHEMISTRY; MENTAL health surveys; NITRIC oxide; VASOCONSTRICTION; PHARMACODYNAMICS
- Publication
Medical Journal of Australia, 1987, Vol 146, p250
- ISSN
0025-729X
- Publication type
journal article
- DOI
10.5694/j.1326-5377.1987.tb120234.x