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- Title
Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma.
- Authors
Xing Yao; Xiang Wang; Zishu Wang; Licheng Dai; Guolei Zhang; Qiang Yan; Weimin Zhou
- Abstract
Background: The aim of this study was to examine the patterns of expression of epithelial-mesenchymal transition (EMT)-related proteins in intrahepatic cholangiocarcinoma. The clinicopathological and prognostic value of these markers was also evaluated. Methods: We detected the expression status of three EMT-related proteins, ie, E-cadherin, vimentin, and N-cadherin, by immunohistochemistry in consecutive intrahepatic cholangiocarcinoma specimens from 96 patients. Results: The frequency of loss of the epithelial marker E-cadherin, and acquisition of mesenchymal markers, vimentin and N-cadherin, in intrahepatic cholangiocarcinoma was 43.8%, 37.5% and 57.3%, respectively. Altered expression of EMT markers was associated with aggressive tumor behavior, including lymph node metastasis, undifferentiated-type histology, advanced tumor stage, venous invasion, and shorter overall survival. Moreover, loss of E-cadherin was retained as an independent prognostic factor for patients with intrahepatic cholangiocarcinoma in multivariate analysis. Conclusion: Our results suggest that the EMT process is associated with tumor progression and a poor outcome in patients with intrahepatic cholangiocarcinoma, and inhibition of EMT might offer novel promising molecular targets for the treatment of affected patients.
- Subjects
CHOLANGIOCARCINOMA; MESENCHYMAL stem cell differentiation; TUMOR diagnosis; CADHERINS; METASTASIS; IMMUNOHISTOCHEMISTRY; THERAPEUTICS; PREVENTION
- Publication
OncoTargets & Therapy, 2012, Vol 5, p255
- ISSN
1178-6930
- Publication type
Article
- DOI
10.2147/OTT.S36213