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- Title
Limited Sampling Strategies for the Estimation of Raltegravir Daily Exposure in HIV-Infected Patients.
- Authors
Cattaneo, Dario; Ripamonti, Diego; Gervasoni, Cristina; Landonio, Simona; Meraviglia, Paola; Baldelli, Sara; Cozzi, Valeria; Fucile, Serena; Clementi, Emilio
- Abstract
Stepwise multiple regression analyses were applied to 50 raltegravir pharmacokinetic profiles from 50 HIV patients with the goal to identify limited sampling strategies for the prediction of drug area under the time–concentration curve (AUC0-12). Raltegravir single sampling point-based equations failed to reliably predict daily drug exposure. Conversely, different algorithms based on few samples and associated with good correlation, acceptable bias, and imprecision with the measured raltegravir AUC0-12 were identified. These models could used to predict raltegravir exposure for clinic or research purposes.
- Subjects
ITALY; ALGORITHMS; COMBINATION drug therapy; STATISTICAL correlation; DOSE-effect relationship in pharmacology; HIV-positive persons; LIQUID chromatography; MASS spectrometry; REGRESSION analysis; RESEARCH funding; MULTIPLE regression analysis; HIGHLY active antiretroviral therapy; DATA analysis software; ATAZANAVIR; ETRAVIRINE (Drug); RALTEGRAVIR; DESCRIPTIVE statistics
- Publication
Journal of Clinical Pharmacology, 2012, Vol 52, Issue 3, p440
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1177/0091270010395939