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- Title
Plasma galectin‐3 levels do not differ in systemic lupus erythematosus patients.
- Authors
Zhao, Chan‐Na; Mao, Yan‐Mei; Liu, Li‐Na; Wu, Qian; Dan, Yi‐Lin; Pan, Hai‐Feng
- Abstract
Objective: To investigate the plasma galectin‐3 levels in systemic lupus erythematosus (SLE) patients and its relations with clinical and laboratory features. Methods: A total of 180 subjects with 90 patients with SLE (8 male, 82 female, mean age 37.86 ± 13.98 years) and 90 healthy controls (8 male, 82 female, mean age 36.54 ± 10.89 years) were included. Plasma galectin‐3 levels were detected by enzyme‐linked immunosorbent assay (ELISA). Results: There was no significant difference in age and gender distribution between SLE patients and healthy controls (both P > .05). Plasma galectin‐3 level was not significantly different between SLE patients and controls (P = .982) (P > .05). No significant difference was found regarding galectin‐3 levels between SLE with nephritis and those without nephritis (P > .05); no significant difference was found between less active SLE and more active SLE (P > .05). Galectin‐3 levels were inversely related to immune globulin M (r = −.303, P < .05), while no significant correlation between galectin‐3 levels and other quantitative laboratory parameters were observed (all P > .05). Conclusions: In summary, plasma galectin‐3 level was not significantly different between SLE patients and controls (P = .982). Further studies are needed to elucidate the role of galectin‐3 in SLE.
- Subjects
GALECTINS; SYSTEMIC lupus erythematosus; ENZYME-linked immunosorbent assay; AGE differences; AGE distribution
- Publication
International Journal of Rheumatic Diseases, 2019, Vol 22, Issue 10, p1820
- ISSN
1756-1841
- Publication type
Article
- DOI
10.1111/1756-185X.13677