We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Age at menarche, ideal cardiovascular health metrics, and risk of diabetes in adulthood: Findings from the REACTION study.
- Authors
Hu, Chunyan; Zhang, Yi; Zhang, Jie; Huo, Yanan; Wan, Qin; Li, Mian; Qi, Hongyan; Du, Rui; Zhu, Yuanyue; Qin, Yingfen; Hu, Ruying; Shi, Lixin; Su, Qing; Yu, Xuefeng; Yan, Li; Qin, Guijun; Tang, Xulei; Chen, Gang; Xu, Min; Wang, Tiange
- Abstract
Background: Age at menarche was reported to be associated with the risk of diabetes. However, the impact of ideal cardiovascular health metrics (ICVHMs) on the association between age at menarche and adulthood diabetes risk was unclear. Methods: We included 121 431 women from the nationwide, population‐based cohort of the REACTION study (Risk Evaluation of Cancers in Chinese Diabetic Individuals: a Longitudinal Study). The diagnosis of diabetes was based on the oral glucose tolerance test (OGTT) and glycosylated hemoglobin (HbA1c) measurement. Logistic regression and multiplicative interaction analysis were conducted to investigate the potential interaction effect between age at menarche and ICVHMs on the development of diabetes. Results: The multivariable‐adjusted odds ratios of diabetes across categories of age at menarche (<14, 14‐17, and > 17 years) were 1.22 (95% confidence interval [CI]: 1.17, 1.28), 1.00 (reference), and 0.89 (95% CI: 0.85, 0.93), respectively. In subgroup analysis, significant interactions were detected between total cholesterol/blood pressure levels and age at menarche regarding the risk of diabetes (P for interaction =.0091 and.0019, respectively). The increased risk associated with age at menarche <14 years was observed in participants with three or fewer ICVHMs, but not in women with four or more ICVHMs (P for interaction =.0001). Conclusions: Age at menarche was inversely associated with the risk of diabetes in adulthood in Chinese women, and it appeared to be modified by the presence of ICVHMs. Further studies are needed to clarify the precise interrelationship and the generalizability of our results.
- Subjects
MENARCHE; GLYCOSYLATED hemoglobin; GLUCOSE tolerance tests; ADULTS; DIABETES
- Publication
Journal of Diabetes, 2021, Vol 13, Issue 6, p458
- ISSN
1753-0393
- Publication type
Article
- DOI
10.1111/1753-0407.13128