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- Title
Use of supra‐therapeutic phenytoin for management of ventricular arrhythmias in children: Case series and literature review.
- Authors
Bhansali, Suneet; Tan, Reina Bianca M.; Spilios, Maria; Cecchin, Frank
- Abstract
Phenytoin is a versatile drug with utility in neurological, dermatological, and even cardiac disease processes. Though phenytoin is widely available due to its excellent anti‐epileptic properties, it is now rarely used as an antiarrhythmic. Phenytoin has well‐studied sodium‐channel blocking abilities which can be taken advantage of to treat ventricular arrhythmias. Thus, it should remain in the arsenal of antiarrhythmics for any electrophysiologist. We present two cases of intractable ventricular arrhythmia in children that were controlled with phenytoin at supra‐therapeutic serum levels, preventing the need for heart transplantation.
- Subjects
THERAPEUTIC use of magnesium; MYOCARDIAL depressants; ANTICONVULSANTS; ECHOCARDIOGRAPHY; SYNCOPE; LIDOCAINE; SODIUM channel blockers; GENETIC mutation; PROPRANOLOL; ISOPROTERENOL; PROCAINAMIDE; PHENYTOIN; EXTRACORPOREAL membrane oxygenation; FLECAINIDE; ESMOLOL; VENTRICULAR arrhythmia; CASE studies; AMIODARONE; ARRHYTHMIA; BRADYCARDIA; VENTRICULAR fibrillation; MEMBRANE proteins; DISEASE complications; CHILDREN
- Publication
Pacing & Clinical Electrophysiology, 2022, Vol 45, Issue 12, p1385
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/pace.14565