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- Title
Immunoglobulin Genes Influence the Magnitude of Humoral Immunity to Cytomegalovirus Glycoprotein B.
- Authors
Pandey, Janardan P.; Kistner-Griffin, Emily; Radwan, Faisal F.; Kaur, Navtej; Namboodiri, Aryan M.; Black, Laurel; Butler, Mary Ann; Carreón, Tania; Ruder, Avima M.
- Abstract
Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (γ marker) genotypes. Anti-HCMV gB antibody levels were highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 µg/mL, respectively; P = .014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases.
- Subjects
IMMUNOGLOBULIN genetics; HUMORAL immunity; CYTOMEGALOVIRUS disease treatment; CYTOMEGALOVIRUS diseases; GLYCOPROTEINS; IMMUNOLOGY
- Publication
Journal of Infectious Diseases, 2014, Vol 210, Issue 11, p1823
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiu367