We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
In vivo potentiation of atracurium neuromuscular blockade by nimodipine in rabbits.
- Authors
Gómez-Iglesias, E.; García, E.; Suarez, E.; Martínez, R.; Rodríguez-Sasiaín, J. M.; Calvo, R.; Gómez-Iglesias, E; García, E; Martínez, R; Rodríguez-Sasiaín, J M
- Abstract
The interaction between nimodipine, a calcium channel blocker, used for the treatment of subarachnoid haemorrhage, and atracurium, was studied in rabbits. An intravenous dose of 0.1 mg.kg-1 of nimodipine given over 3 min caused a potentiation of the neuromuscular blocking action of atracurium (administered at an infusion rate of 7.5 micrograms.kg-1.min-1), measured on the indirectly stimulated tibialis-anterior muscle of the animal. (ED50)inf and (ED95)inf were significantly reduced (30.7% and 23.3%) in nimodipine-treated animals (P less than 0.05 and P less than 0.02, respectively). No changes were observed in recovery rate.
- Publication
Acta Anaesthesiologica Scandinavica, 1992, Vol 36, Issue 1, p67
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1111/j.1399-6576.1992.tb03424.x