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- Title
Delayed F-fluorodeoxyglucose PET/CT imaging improves quantitation of atherosclerotic plaque inflammation: Results from the CAMONA study.
- Authors
Blomberg, Björn; Thomassen, Anders; Takx, Richard; Hildebrandt, Malene; Simonsen, Jane; Buch-Olsen, Karen; Diederichsen, Axel; Mickley, Hans; Alavi, Abass; Høilund-Carlsen, Poul
- Abstract
Background: This study aimed to determine if delayed F-fluorodeoxyglucose (FDG) PET/CT imaging improves quantitation of atherosclerotic plaque inflammation. Blood-pool activity can disturb the arterial FDG signal. With time, blood-pool activity declines. Therefore, delayed imaging can potentially improve quantitation of vascular inflammation. Methods and Results: 40 subjects were prospectively assessed by dual-time-point PET/CT imaging at approximately 90 and 180 minutes after FDG administration. For both time-points, global uptake of FDG was determined in the carotid arteries and thoracic aorta by calculating the blood-pool corrected maximum standardized uptake value (cSUV). A target-to-background ratio (TBR) was calculated to determine the contrast resolution at 90 and 180 minutes. Furthermore, we assessed whether the acquisition time-point affected the relation between cSUV and the estimated 10-year risk for fatal cardiovascular disease (SCORE %). A significant increase in carotid cSUV (23%, P < .0001), carotid TBR (20%, P < .0001), aortic cSUV (14%, P < .0001), and aortic TBR (20%, P < .0001) was observed with time. At 90 minutes, cSUV did not relate to SCORE %, whereas at 180 minutes significant positive relations were observed between SCORE % and carotid ( τ = 0.25, P = .045) and aortic ( τ = 0.33, P = .008) cSUV. Conclusions: Delayed FDG PET/CT imaging at 180 minutes improves quantitation of atherosclerotic plaque inflammation over imaging at 90 minutes. Therefore, the optimal acquisition time-point to assess atherosclerotic plaque inflammation lies beyond the advocated time-point of 90 minutes after FDG administration.
- Subjects
ATHEROSCLEROTIC plaque; INFLAMMATION; DIAGNOSTIC imaging; POSITRON emission tomography; CARDIOVASCULAR diseases; CARDIOLOGY; RADIOLOGY
- Publication
Journal of Nuclear Cardiology, 2014, Vol 21, Issue 3, p588
- ISSN
1071-3581
- Publication type
Article
- DOI
10.1007/s12350-014-9884-6