We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Predicting immune checkpoint inhibitor response in urothelial carcinoma: another step in personalised medicine?
- Authors
Niegisch, Günter
- Abstract
Prediction of treatment response is a crucial issue in individualised treatment for cancer patients. In this context, Nassar and colleagues in the accompanying study published in the British Journal of Cancer analysed retrospectively a cohort of 62 metastatic urothelial cancer patients treated with immune checkpoint inhibitors and of whom not only clinical but also genomic characteristics were available. Combining molecular and clinical factors in a multivariable analysis they identified lack of visceral metastases, neutrophil-to-lymphocyte ratio (NLR) <5, and high single nucleotide variant (SNV) count (≥10) as independent predictors of treatment response.
- Subjects
RETROSPECTIVE studies; PROGNOSIS; NEUTROPHILS; LYMPHOCYTES; GENOMICS; ANTIGENS
- Publication
British Journal of Cancer, 2020, Vol 122, Issue 4, p453
- ISSN
0007-0920
- Publication type
editorial
- DOI
10.1038/s41416-019-0684-2