We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Postoperative wound infection. A poor prognostic sign for patients with head and neck cancer.
- Authors
Grandis, Jennifer R.; Snyderman, Carl H.; Johnson, Jonas T.; Yu, Victor L.; D'Amico, Frank; Grandis, J R; Snyderman, C H; Johnson, J T; Yu, V L; D'Amico, F
- Abstract
<bold>Background: </bold>The development of a wound infection has been identified as a favorable prognostic factor after oncologic surgical procedures.<bold>Methods: </bold>The authors retrospectively studied the relationship between postoperative wound infection, local/regional tumor recurrence, and survival rates in 134 patients undergoing therapeutic surgical resection for squamous cell carcinoma of the head and neck (SCCHN).<bold>Results: </bold>The median age was 61 years (range, 25-87 years) with most (75%) patients having advanced disease (Stage III or IV). Patients without evidence of recurrent disease were followed up for a median time of 34 months (range, 24-68 months). Twenty-nine (22%) had local or regional bacterial infections develop postoperatively. Recurrence rates were increased (P = 0.008) in patients with postoperative wound infections compared with patients who had distant infections, e.g., pneumonia or urinary tract infection, or no infection. Disease-free survival also was adversely affected (P = 0.04) in this group. Both advanced tumor stage and postoperative wound infections were independently associated with decreased survival, with odds ratios of 2:3 and 2:4, respectively.<bold>Conclusions: </bold>These data contrast with other reports in the literature of a beneficial effect of postoperative wound infection on outcome. These findings suggest a possible relationship between local/regional immune function and postoperative infection in patients with SCCHN:
- Publication
Cancer (0008543X), 1992, Vol 70, Issue 8, p2166
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19921015)70:8<2166::AID-CNCR2820700826>3.0.CO;2-H