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- Title
Expression of PRAD1/cyclin D1 in plasma cell malignancy: incidence and prognostic aspects.
- Authors
HATA, HIROYUKI; KURIBAYASHI, NORIOMI; YOSHIDA, MINORU; HARADA, NAOKO; NAGASAKI, AKITOSHI; KIMURA, TATSUYA; MATSUNO, FUMIHIKO; MITSUYA, HIROAKI; MATSUZAKI, HIROMITSU; Sonoki, Takashi
- Abstract
We analysed PRAD1/cyclin D1 expression in 20 patients with plasma cell malignancy by Northern analysis. 6/17 multiple myeloma patients and 3/3 plasma cell leukaemia patients showed PRAD1/cyclin D1 expression. This incidence appeared to be higher than the expected incidence based on previous studies. Southern analysis did not show rearrangement of the bcl-1 region. Although there was no statistical difference, the PRAD1/cyclin D1 negative group showed a 1-year survival of 81.8%, 3-year survival of 45.5% and 5-year survival of 22.7%, and those for the PRAD1/cyclin D1 positive group were 63.5%, 16.9% and 16.9%, respectively. Further study is required to determine whether PRAD1/cyclin D1 expression is a prognostic factor.
- Subjects
DNA; LEUKEMIA; MULTIPLE myeloma; IMMUNOGLOBULIN genes; PATIENTS
- Publication
British Journal of Haematology, 1999, Vol 104, Issue 3, p614
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.1999.01204.x