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- Title
Dynamic Prediction of Survival for Sinonasal Extranodal Natural Killer/T‐cell Lymphoma.
- Authors
Wang, Taiqin; Qiu, Yanyan; Shi, Liangwen; Chen, Dongxu; Chen, Xiaoqiang; Liu, Jianzhi; Liu, Tingbo
- Abstract
Background: Extranodal natural killer/ T‐cell lymphoma (ENKTL) is a rare malignant tumor. This study aimed to develop a predictive nomogram and a web‐based survival rate calculator for dynamically predicting the survival of patients with sinonasal ENKTL (SN‐ENKTL). Methods: This study investigated patients (n = 134) with SN‐ENKTL who had been initially treated in our hospital between Jan 2008 and Dec 2016. The patients were randomly divided into training and validation cohorts, in a 7:3 ratio. Independent prognostic factors were identified and integrated to build a predictive nomogram and a web‐based calculator using the Cox‐regression model. The nomogram was evaluated by consistency index and calibration curve. Results: Age, lactate dehydrogenase, hemoglobin, Epstein–Barr virus DNA, and Ann Arbor stage were identified as independent risk factors. We constructed a predictive nomogram for survival and a web‐based calculator (https://taiqinwang.shinyapps.io/DynNomapp/). Conclusion: This study developed a prognostic model and a web‐based calculator specifically focused on SN‐ENKTL for otolaryngologists to use to facilitate timely treatment decisions for the disease. Level of Evidence: 4 Laryngoscope, 133:1645–1651, 2023
- Subjects
PARANASAL sinuses; T-cell lymphoma; LYMPHOMAS; LACTATE dehydrogenase; OVERALL survival
- Publication
Laryngoscope, 2023, Vol 133, Issue 7, p1645
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.30342