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- Title
Effects of a Lifestyle Intervention During Pregnancy and First Postpartum Year: Findings From the RADIEL Study.
- Authors
Huvinen, Emilia; Koivusalo, Saila B; Meinilä, Jelena; Valkama, Anita; Tiitinen, Aila; RöNö, Kristiina; Stach-Lempinen, Beata; Eriksson, Johan G
- Abstract
<bold>Context: </bold>Women with a history of gestational diabetes (GDM) have a sevenfold risk of developing type 2 diabetes.<bold>Objective: </bold>To assess the effects of a lifestyle intervention during pregnancy and first postpartum year on glucose regulation, weight retention, and metabolic characteristics among women at high GDM risk.<bold>Design: </bold>In the Finnish Gestational Diabetes Prevention study, trained study nurses provided lifestyle counseling in each trimester and 6 weeks, 6 months, and 12 months postpartum.<bold>Setting: </bold>Three maternity hospitals in the Helsinki area and one in Lappeenranta.<bold>Patients: </bold>In total, 269 women with previous GDM and/or a prepregnancy body mass index ≥30 kg/m2 were enrolled before 20 gestational weeks and allocated to either a control or an intervention group. This study includes the 200 participants who attended study visits 6 weeks and/or 12 months postpartum.<bold>Intervention: </bold>The lifestyle intervention followed Nordic diet recommendations and at least 150 minutes of moderate exercise was recommended weekly.<bold>Main Outcome Measure: </bold>The incidence of impaired glucose regulation (impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes) during the first postpartum year.<bold>Results: </bold>Impaired glucose regulation was present in 13.3% of the women in the control and in 2.7% in the intervention group [age-adjusted odds ratio, 0.18 (95% confidence interval, 0.05 to 0.65), P = 0.009] during the first postpartum year. There were no differences between the groups in weight retention, physical activity, or diet at 12 months postpartum.<bold>Conclusions: </bold>A lifestyle intervention during pregnancy and the first postpartum year successfully reduced the incidence of postpartum impairment in glucose regulation.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2018, pN.PAG
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2017-02477