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- Title
Metallomics approach to changes in element concentration during differentiation from fibroblasts into adipocytes by element array analysis.
- Authors
Yasumitsu Ogra; Shu Nagasaki; Ayako Yawata; Yasumi Anan; Koichi Hamada; Akihiro Mizutani
- Abstract
We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3- L1 mouse fibroblasts into adipocytes. This metallomics approach yielded unique information of cellular response to physiological and toxicological events.
- Subjects
FIBROBLASTS; FAT cells; ADIPOSE tissues; METALLOCENES; TOXICITY testing
- Publication
Journal of Toxicological Sciences, 2016, Vol 41, Issue 2, p241
- ISSN
0388-1350
- Publication type
Article
- DOI
10.2131/jts.41.241