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- Title
IA-Body Composition CT at T12 in Idiopathic Pulmonary Fibrosis: Diagnosing Sarcopenia and Correlating with Other Morphofunctional Assessment Techniques.
- Authors
Fernández-Jiménez, Rocío; Sanmartín-Sánchez, Alicia; Cabrera-César, Eva; Espíldora-Hernández, Francisco; Vegas-Aguilar, Isabel; Amaya-Campos, María del Mar; Palmas-Candia, Fiorella Ximena; Claro-Brandner, María; Olivares-Alcolea, Josefina; Simón-Frapolli, Víctor José; Cornejo-Pareja, Isabel; Guirado-Peláez, Patricia; Vidal-Suárez, Álvaro; Sánchez-García, Ana; Murri, Mora; Garrido-Sánchez, Lourdes; Tinahones, Francisco J.; Velasco-Garrido, Jose Luis; García-Almeida, Jose Manuel
- Abstract
Background: Body composition (BC) techniques, including bioelectrical impedance analysis (BIVA), nutritional ultrasound® (NU), and computed tomography (CT), can detect nutritional diagnoses such as sarcopenia (Sc). Sc in idiopathic pulmonary fibrosis (IPF) is associated with greater severity and lower survival. Our aim was to explore the correlation of BIVA, NU and functional parameters with BC at T12 level CT scans in patients with IPF but also its relationship with degree of Sc, malnutrition and mortality. Methods: This bicentric cross-sectional study included 60 IPF patients (85.2% male, 70.9 ± 7.8 years). Morphofunctional assessment (MFA) techniques included BIVA, NU, CT at T12 level (T12-CT), handgrip strength, and timed up and go. CT data were obtained using FocusedON®. Statistical analysis was conducted using JAMOVI version 2.3.22 to determine the cutoff points for Sc in T12-CT and to analyze correlations with other MFA techniques. Results: the cutoff for muscle area in T12-CT was ≤77.44 cm2 (area under the curve (AUC) = 0.734, sensitivity = 41.7%, specificity = 100%). The skeletal muscle index (SMI_T12CT) cutoff was ≤24.5 cm2/m2 (AUC = 0.689, sensitivity = 66.7%, specificity = 66.7%). Low SMI_T12CT exhibited significantly reduced median survival and higher risk of mortality compared to those with normal muscle mass (SMI cut off ≥ 28.8 cm/m2). SMI_T12CT was highly correlated with body cell mass from BIVA (r = 0.681) and rectus femoris cross-sectional area (RF-CSA) from NU (r = 0.599). Cronbach's α for muscle parameters across different MFA techniques and CT was 0.735, confirming their validity for evaluating muscle composition. Conclusions: T12-CT scan is a reliable technique for measuring low muscle mass in patients with IPF, specifically when the L3 vertebrae are not captured. An SMI value of <28.8 is a good predictor of low lean mass and 12-month mortality in IPF patients.
- Subjects
SPAIN; MORTALITY risk factors; RISK assessment; STATISTICAL correlation; CROSS-sectional method; MALNUTRITION; RECEIVER operating characteristic curves; CRONBACH'S alpha; RESEARCH funding; BODY composition; NUTRITIONAL assessment; FUNCTIONAL assessment; BIOELECTRIC impedance; DESCRIPTIVE statistics; SEVERITY of illness index; RESEARCH; IDIOPATHIC pulmonary fibrosis; DATA analysis software; SARCOPENIA; GRIP strength; SENSITIVITY &; specificity (Statistics); DISEASE risk factors
- Publication
Nutrients, 2024, Vol 16, Issue 17, p2885
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16172885