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- Title
Association between PD-1 single nucleotide gene variants and the risk of metastatic melanoma.
- Authors
Boutros, Andrea; Carosio, Roberta; Campanella, Dalila; Banelli, Barbara; Morabito, Anna; Pistillo, Maria Pia; Croce, Elena; Queirolo, Paola; Tanda, Enrica Teresa; Raposio, Edoardo; Fontana, Vincenzo; Spagnolo, Francesco
- Abstract
Previous studies showed an association between single nucleotide gene variants (SNVs) of PD-1 and cancer susceptibility. We analyzed PD1.5 C > T and PD1.7 T > C SNVs to investigate their association with the risk of developing metastatic melanoma (MM). Utilizing a cohort of 125 MM patients treated with anti-PD-1 agents and 84 healthy controls, we examined genotype/allele frequencies through a modified Poisson regression model, adjusted for age and sex. Our findings indicate that the PD1.5 T allele is associated with a reduced risk of MM, showing a significantly lower risk in both codominant (RR = 0.56, 95%CL: 0.37–0.87) and dominant (RR = 0.73 95%CL: 0.59–0.90) models. Conversely, the PD1.7 C allele is linked to an increased risk of MM, with the C/C genotype exhibiting a higher risk in the codominant (RR = 1.65, 95%CL: 1.32–2.05) and allelic (RR = 1.23, 95%CL: 1.06–1.43) models. These results are consistent with previous meta-analyses on other cancer types, mainly highlighting the PD1.5 SNV’s potential role in promoting anti-tumor immunity through increased PD1-positive circulating effector T cell activity.
- Publication
Archives of Dermatological Research, 2024, Vol 316, Issue 7, p1
- ISSN
0340-3696
- Publication type
Article
- DOI
10.1007/s00403-024-03034-9