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- Title
Palladium‐Catalyzed Selective Syntheses of 2,3‐Allenyl Amines via Double Functionalization Coupling of 2‐Alkynyl‐1,4‐diol Dicarbonates.
- Authors
Zhou, Zhengnan; Li, Can; Ma, Shengming
- Abstract
Comprehensive Summary: 2,3‐Allenyl amines have shown wide applicability in biomedical and synthetic applications. Due to their enormous potential for applications, researchers have been dedicated to the development of methods for synthesizing 2,3‐allenyl amines. Herein, a palladium‐catalyzed three‐component reaction of 2‐alkynyl‐1,4‐diol dicarbonates, organoboronic acids, and nitrogen nucleophiles forming 2,3‐allenyl amines with excellent regio‐ and chemo‐selectivity has been developed. Substrate compatibility and synthetic applications have been demonstrated. Control experiments supported a mechanism involving 1,2,3‐triene‐Pd species and methylene‐π‐allyl palladium species.
- Subjects
RESEARCH personnel; CHEMOSELECTIVITY; PALLADIUM; NUCLEOPHILES; AMINES; BORONIC acids; GLYCOLS
- Publication
Chinese Journal of Chemistry, 2024, Vol 42, Issue 19, p2357
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202400298