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- Title
Monocyte Production of C1q Potentiates CD8<sup>+</sup> T-Cell Function Following Respiratory Viral Infection.
- Authors
Eddens, Taylor; Parks, Olivia B.; Lou, Dequan; Fan, Li; Sojati, Jorna; Ramsey, Manda Jo; Schmitt, Lori; Salgado, Claudia M.; Reyes-Mugica, Miguel; Evans, Alysa; Zou, Henry M.; Oury, Tim D.; Byersdorfer, Craig; Chen, Kong; Williams, John V.
- Abstract
Respiratory viral infections remain a leading cause of morbidity and mortality. Using a murine model of human metapneumovirus, we identified recruitment of a C1q-expressing inflammatory monocyte population concomitant with viral clearance by adaptive immune cells. Genetic ablation of C1q led to reduced CD8+ T-cell function. Production of C1q by a myeloid lineage was necessary to enhance CD8+ T-cell function. Activated and dividing CD8+ T cells expressed a C1q receptor, gC1qR. Perturbation of gC1qR signaling led to altered CD8+ T-cell IFN-γ production, metabolic capacity, and cell proliferation. Autopsy specimens from fatal respiratory viral infections in children exhibited diffuse production of C1q by an interstitial population. Humans with severe coronavirus disease (COVID-19) infection also exhibited upregulation of gC1qR on activated and rapidly dividing CD8+ T cells. Collectively, these studies implicate C1q production from monocytes as a critical regulator of CD8+ T-cell function following respiratory viral infection.
- Subjects
RESPIRATORY infections in children; VIRUS diseases; COVID-19; RESPIRATORY infections; T cells
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2024, Vol 71, Issue 3, p294
- ISSN
1044-1549
- Publication type
Article
- DOI
10.1165/rcmb.2024-0004OC