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The tauopathy‐associated PERK variant, PERK‐B, induces maladaptive translation and reveals novel pathogenic mechanisms of PSP.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082832
By:
- Lessard, Christian B;
- Tolton, Samantha G;
- McFarland, Karen;
- Criado‐Marrero, Marangelie;
- Bagchi, Pritha;
- Seyfried, Nicholas T;
- Abisambra, Jose F. F
Publication type:
Article
Altered brain connectivity, neuroinflammation and AD‐related markers following 7 days after repetitive mild traumatic brain injury in young wild‐type mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076626
By:
- Criado‐Marrero, Marangelie;
- Ravi, Sakthivel;
- Hery, Gabriela P;
- Bolen, Mackenzie L;
- Febo, Marcelo;
- Grudny, Matteo M;
- Prokop, Stefan;
- Abisambra, Jose F. F
Publication type:
Article
P301L‐Tau Expression Induces Skeletal Muscle Abnormalities in Mouse Model of Tauopathy.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080028
By:
- Alava, Bryan;
- Esser, Karyn;
- Abisambra, Jose F. F
Publication type:
Article
P301L‐Tau Expression Induces Skeletal Muscle Abnormalities in Mouse Model of Tauopathy.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080028
By:
- Alava, Bryan;
- Esser, Karyn;
- Abisambra, Jose F. F
Publication type:
Article
Tau‐RNA complexes contribute to the pathogenesis and progression in Alzheimer's disease and related tauopathies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069399
By:
- Lessard, Christian B;
- Koren, John;
- Abisambra, Jose F. F
Publication type:
Article
Hypomorphic PERK promotes a maladaptive phenotype in response to pathologic tau.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.068002
By:
- Lessard, Christian B;
- Tolton, Samantha G;
- Abisambra, Jose F. F
Publication type:
Article
Grip Strength as a Potential Biomarker for Insoluble Tau Accumulation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.067957
By:
- Alava, Bryan;
- Esser, Karyn;
- Abisambra, Jose F. F
Publication type:
Article
Novel small chemical compound with NFAT modulatory properties alleviates synaptic dysfunction and improves cognition in mouse models of amyloid pathology: Preclinical small‐molecule drug discovery.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043858
By:
- Sompol, Pradoldej;
- Gollihue, Jenna L.;
- Cloyd, Ryan;
- Koren, Shon;
- Nation, Grant K.;
- Abisambra, Jose F.;
- Artiushin, Irina A.;
- Kraner, Susan D.;
- Huzian, Orsolya;
- Hackler, Laszlo;
- Puskas, Laszlo G.;
- Norris, Christopher M.
Publication type:
Article
PERK inhibition promotes the rescue of protein translation and Nrf2‐related antioxidant response: Molecular and cell biology/oxidative stress.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041867
By:
- Lanzillotta, Chiara;
- Zuliani, Ilaria;
- Tramutola, Antonella;
- Abisambra, Jose F.;
- Barone, Eugenio;
- Perluigi, Marzia;
- Domenico, Fabio Di
Publication type:
Article
Presentation 3: Translational dysregulation promotes pathogenic events in tauopathies: Dysregulation of protein synthesis in neurodegeneration.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.039191
By:
- Koren, Shon;
- Meier, Shelby E;
- Abisambra, Jose F.
Publication type:
Article
Proteomic Techniques to Examine Neuronal Translational Dynamics.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 14, p. 3524, doi. 10.3390/ijms20143524
By:
- Koren, Shon A.;
- Gillett, Drew A.;
- D'Alton, Simon V.;
- Hamm, Matthew J.;
- Abisambra, Jose F.
Publication type:
Article
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.
Published in:
Translational Psychiatry, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41398-021-01349-z
By:
- Lyra e Silva, Natalia M.;
- Gonçalves, Rafaella A.;
- Pascoal, Tharick A.;
- Lima-Filho, Ricardo A. S.;
- Resende, Elisa de Paula França;
- Vieira, Erica L. M.;
- Teixeira, Antonio L.;
- de Souza, Leonardo C.;
- Peny, Julyanna A.;
- Fortuna, Juliana T. S.;
- Furigo, Isadora C.;
- Hashiguchi, Debora;
- Miya-Coreixas, Vivian S.;
- Clarke, Julia R.;
- Abisambra, Jose F.;
- Longo, Beatriz M.;
- Donato, Jose;
- Fraser, Paul E.;
- Rosa-Neto, Pedro;
- Caramelli, Paulo
Publication type:
Article
Chaperone-mediated modulation of tau aggregation correlates with modifications in tau pathology and synaptic plasticity
Published in:
2010
By:
- Abisambra, Jose F.;
- Blair, Laura J.;
- Jones, Jeffrey R.;
- Kraft, Clara;
- Hill, Shannon;
- Rogers, Justin;
- Koren, John;
- Jinwal, Umesh K.;
- Lawson, Lisa;
- Johnson, Amelia G.;
- Jansen-West, Karen;
- Muschol, Martin;
- Banko, Jessica;
- Golde, Todd;
- Weeber, Edwin J.;
- Dickey, Chad A.
Publication type:
Abstract
The early involvement of chaperones in tau pathogenesis
Published in:
2010
By:
- Dickey, Chad A.;
- O'Leary, John C.;
- Borysov, Sergiy;
- Koren, John;
- Jones, Jeffrey;
- Lawson, Lisa;
- Blair, Laura;
- Jin, Ying;
- Abisambra, Jose F.;
- Li, Qingyou;
- Jinwal, Umesh K.
Publication type:
Abstract
LDLR Expression and Localization Are Altered in Mouse and Human Cell Culture Models of Alzheimer's Disease.
Published in:
PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008556
By:
- Abisambra, Jose F.;
- Fiorelli, Tina;
- Padmanabhan, Jaya;
- Neame, Peter;
- Wefes, Inge;
- Potter, Huntington
Publication type:
Article
Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy.
Published in:
European Heart Journal, 2023, v. 44, n. 17, p. 1560, doi. 10.1093/eurheartj/ehad205
By:
- Luciani, Marco;
- Montalbano, Mauro;
- Troncone, Luca;
- Bacchin, Camilla;
- Uchida, Keita;
- Daniele, Gianlorenzo;
- Wolf, Bethany Jacobs;
- Butler, Helen M;
- Kiel, Justin;
- Berto, Stefano;
- Gensemer, Cortney;
- Moore, Kelsey;
- Morningstar, Jordan;
- Diteepeng, Thamonwan;
- Albayram, Onder;
- Abisambra, José F;
- Norris, Russell A;
- Salvo, Thomas G Di;
- Prosser, Benjamin;
- Kayed, Rakez
Publication type:
Article
RNA binding proteins co-localize with small tau inclusions in tauopathy.
Published in:
Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0574-5
By:
- Maziuk, Brandon F.;
- Apicco, Daniel J.;
- Cruz, Anna Lourdes;
- Jiang, Lulu;
- Ash, Peter E. A.;
- da Rocha, Edroaldo Lummertz;
- Zhang, Cheng;
- Yu, Wai Haung;
- Leszyk, John;
- Abisambra, Jose F.;
- Li, Hu;
- Wolozin, Benjamin
Publication type:
Article
The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 2, p. 591, doi. 10.1523/JNEUROSCI.4815-09.2010
By:
- Jinwal, Umesh K.;
- Koren III, John;
- Borysov, Sergiy I.;
- Schmid, Andreas B.;
- Abisambra, Jose F.;
- Blair, Laura J.;
- Johnson, Amelia G.;
- Jones, Jeffrey R.;
- Shults, Cody L.;
- O'Leary III, John C.;
- Ying Jin;
- Buchner, Johannes;
- Cox, Marc B.;
- Dickey, Chad A.
Publication type:
Article
Imbalance of Hsp70 family variants fosters tau accumulation.
Published in:
FASEB Journal, 2013, v. 27, n. 4, p. 1450, doi. 10.1096/fj.12-220889
By:
- Jinwal, Umesh K.;
- Akoury, Elias;
- Abisambra, Jose F.;
- O'Leary III, John C.;
- Thompson, Andrea D.;
- Blair, Laura J.;
- Ying Jin;
- Bacon, Justin;
- Nordhues, Bryce A.;
- Cockman, Matthew;
- Zhang, Juan;
- Pengfei Li;
- Bo Zhang;
- Borysov, Sergiy;
- Uversky, Vladimir N.;
- Biernat, Jacek;
- Mandelkow, Eckhard;
- Gestwicki, Jason E.;
- Zweckstetter, Markus;
- Dickey, Chad A.
Publication type:
Article
MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.
Published in:
PLoS ONE, 2016, v. 11, n. 2, p. 1, doi. 10.1371/journal.pone.0149451
By:
- Bachstetter, Adam D.;
- Zhou, Zhengqiu;
- Rowe, Rachel K.;
- Xing, Bin;
- Goulding, Danielle S.;
- Conley, Alyssa N.;
- Sompol, Pradoldej;
- Meier, Shelby;
- Abisambra, Jose F.;
- Lifshitz, Jonathan;
- Watterson, D. Martin;
- Van Eldik, Linda J.
Publication type:
Article
Tau drives translational selectivity by interacting with ribosomal proteins.
Published in:
Acta Neuropathologica, 2019, v. 137, n. 4, p. 571, doi. 10.1007/s00401-019-01970-9
By:
- Koren, Shon A.;
- Hamm, Matthew J.;
- Abisambra, Jose F.;
- Meier, Shelby E.;
- Weiss, Blaine E.;
- Nation, Grant K.;
- Chishti, Emad A.;
- Arango, Juan Pablo;
- Chen, Jing;
- Zhu, Haining;
- Blalock, Eric M.
Publication type:
Article
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.
Published in:
Molecular Neurodegeneration, 2010, v. 5, p. 45, doi. 10.1186/1750-1326-5-45
By:
- O'Leary, III., John C.;
- Qingyou Li;
- Marinec, Paul;
- Blair, Laura J.;
- Congdon, Erin E.;
- Johnson, Amelia G.;
- Jinwal, Umesh K.;
- Koren, III., John;
- Jones, Jeffrey R.;
- Kraft, Clara;
- Peters, Melinda;
- Abisambra, Jose F.;
- Duff, Karen E.;
- Weeber, Edwin J.;
- Gestwicki, Jason E.;
- Dickey, Chad A.
Publication type:
Article
Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology.
Published in:
Aging Cell, 2021, v. 20, n. 7, p. 1, doi. 10.1111/acel.13416
By:
- Sompol, Pradoldej;
- Gollihue, Jenna L.;
- Kraner, Susan D.;
- Artiushin, Irina A.;
- Cloyd, Ryan A.;
- Chishti, Emad A.;
- Koren, Shon A.;
- Nation, Grant K.;
- Abisambra, Jose F.;
- Huzian, Orsolya;
- Nagy, Lajos I.;
- Santha, Miklos;
- Hackler, Laszlo;
- Puskas, Laszlo G.;
- Norris, Christopher M.
Publication type:
Article
Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis.
Published in:
Journal of Neuroscience, 2016, v. 36, n. 3, p. 1001, doi. 10.1523/JNEUROSCI.3029-15.2016
By:
- Meier, Shelby;
- Bell, Michelle;
- Lyons, Danielle N.;
- Rodriguez-Rivera, Jennifer;
- Ingram, Alexandria;
- Fontaine, Sarah N.;
- Mechas, Elizabeth;
- Jing Chen;
- Wolozin, Benjamin;
- LeVine III, Harry;
- Haining Zhu;
- Abisambra, Jose F.
Publication type:
Article
Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation.
Published in:
Journal of Neuroscience, 2013, v. 33, n. 22, p. 9498, doi. 10.1523/JNEUROSCI.5397-12.2013
By:
- Abisambra, Jose F.;
- Jinwa, Umesh K.;
- Blair, Laura J.;
- O'Leary III, John C.;
- Qingyou Li;
- Brady, Sarah;
- Li Wang;
- Guidi, Chantal E.;
- Bo Zhang;
- Nordhues, Bryce A.;
- Cockman, Matthew;
- Suntharalingham, Amirthaa;
- Pengfei Li;
- Ying Jin;
- Atkins, Christopher A.;
- Dickey, Chad A.
Publication type:
Article
ApoER2 Function in the Establishment and Maintenance of Retinal Synaptic Connectivity.
Published in:
Journal of Neuroscience, 2011, v. 31, n. 40, p. 14413, doi. 10.1523/JNEUROSCI.3135-11.2011
By:
- Trotter, Justin H.;
- Klein, Martin;
- Jinwal, Umesh K.;
- Abisambra, Jose F.;
- Dickey, Chad A.;
- Tharkur, Jeremy;
- Masiulis, Irene;
- Ding, Jindong;
- Locke, Kirsten G.;
- Rickman, Catherine Bowes;
- Birch, David G.;
- Weeber, Edwin J.;
- Herz, Joachim
Publication type:
Article
Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 46, p. 15374, doi. 10.1523/JNEUROSCI.3155-10.2010
By:
- Abisambra, Jose F.;
- Blair, Laura J.;
- Hill, Shannon E.;
- Jones, Jeffrey R.;
- Kraft, Clara;
- Rogers, Justin;
- Koren III, John;
- Jinwal, Umesh K.;
- Lawson, Lisa;
- Johnson, Amelia G.;
- Wilcock, Donna;
- O'Leary, John C.;
- Jansen-West, Karen;
- Muschol, Martin;
- Golde, Todd E.;
- Weeber, Edwin J.;
- Banko, Jessica;
- Dickey, Chad A.
Publication type:
Article

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