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- Title
Analysis of Gene Expression Profiles Associated with Functional Recovery After Spinal Cord Injury Caused by Sema4D Knockdown in Oligodendrocytes.
- Authors
Zhang, Hong-Lei; Jiang, Zhen-Song; Wang, Fu-Wu
- Abstract
We previously showed that sema4D Knockdown in oligodendrocytes promotes functional recovery after spinal cord injury. In this paper, we examined gene expression profiles associated with functional recovery by PCR array. For general observation during first 4 weeks, we found that sema4D knockdown could reduce edema and stimulate SCEP. Further, PCR array analysis indicated sema4D knockdown in OPCs inhibited wound tissue angiogenesis and inflammation genes expression and upregulated axon regeneration genes expression at early phase. Our findings provided the molecular mechanism for its potential application.
- Subjects
GENE expression; SPINAL cord injuries; SEMAPHORINS; OLIGODENDROGLIA; EDEMA; POLYMERASE chain reaction
- Publication
Cell Biochemistry & Biophysics, 2014, Vol 69, Issue 3, p655
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-014-9848-0