We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance.
- Authors
Shin-ichiro Imai
- Abstract
Abstract For the past several years, it has been demonstrated that the NAD-dependent protein deacetylase Sirt1 and nicotinamide phosphoribosyltransferase (Nampt)-mediated systemic NAD biosynthesis together play a critical role in the regulation of metabolism and possibly aging in mammals. Based on our recent studies on these two critical components, we have developed a hypothesis of a novel systemic regulatory network, named “NAD World”, for mammalian aging. Conceptually, in the NAD World, systemic NAD biosynthesis mediated by intra- and extracellular Nampt functions as a driver that keeps up the pace of metabolism in multiple tissues/organs, and the NAD-dependent deacetylase Sirt1 serves as a universal mediator that executes metabolic effects in a tissue-dependent manner in response to changes in systemic NAD biosynthesis. This new concept of the NAD World provides important insights into a systemic regulatory mechanism that fundamentally connects metabolism and aging and also conveys the ideas of functional hierarchy and frailty for the regulation of metabolic robustness and aging in mammals.
- Subjects
DEVELOPMENTAL biology; METABOLIC regulation; BIOSYNTHESIS; BIOCHEMICAL engineering
- Publication
Cell Biochemistry & Biophysics, 2009, Vol 53, Issue 2, p65
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-008-9041-4