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- Title
A retrospective analysis of radiation therapy for the treatment of feline vaccine-associated sarcoma.
- Authors
Eckstein, C.; Guscetti, F.; Roos, M.; de las Mulas, J. Martín; Kaser-Hotz, B.; Bley, C. Rohrer
- Abstract
We retrospectively evaluated predictive prognostic factors in 73 cats with vaccine-associated sarcoma given postsurgical curative ( n = 46, most with clean margins) or coarse fractionated radiotherapy ( n = 27, most with either macroscopic disease or dirty margins). The former animals displayed a median survival of 43 months and a median progression free interval (PFI) of 37 months, the latter reached a median survival of 24 months and a median PFI of 10 months. In cats undergoing coarse fractionated therapy, factors predictive of a better outcome included lack of visible mass ( n = 10) as opposed to macroscopic disease ( n = 17, survival: 30 versus 7 months, P = 0.025; PFI: 20 versus 4 months, P = 0.01), adjuvant chemotherapy for gross disease ( n = 5/17, survival: 29 versus 5 months, P = 0.04) and a smaller number of surgeries preceding radiation therapy (coeff = 0.41, P = 0.03). The Ki67 index was not predictive for survival. We concluded that postsurgical curative and coarse fractionated radiotherapy are effective legitimate options for managing vaccine-associated sarcomas.
- Subjects
RADIOTHERAPY; CATS as laboratory animals; CAT diseases; SARCOMA; CURATIVE medicine; DRUG therapy
- Publication
Veterinary & Comparative Oncology, 2009, Vol 7, Issue 1, p54
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5829.2008.00173.x